Introduction: Aggressive nature killer-cell leukemia (ANKL) is a rare, highly lethal and disseminated malignancy derived from NK cells. Patients are most commonly young to middle aged adults who present with constitutional symptoms and often have organomegaly, hemophagocytosis, and multiorgan failure....
图片来源:Cell, doi: 10.1016/j.cell.2020.02.029; 康橙投资 02 NK细胞的表型及特征 基于细胞表面蛋白表达对细胞进行免疫分型是生物医学研究中的常用方法,实践中多采用流式细胞技术(Flow Cytometry),分型依据是免疫荧光检测信号的有无(采用“+/-”或“positi...
In the last years, immune-directed therapies such as chimeric antigen receptor (CAR)-T cells were introduced, which showed outstanding clinical activity against B-cell malignancies including acute lymphoblastic leukemia (ALL). However, the application of CAR-T cells appears to be challenging due to...
Results from multivariable analysis showed that NK-cell admin- istration was associated with a significantly decreased risk of disease relapse vs. controls (HR of controls 13.76; 95% CI Leukemia (2022) 36:155 – 164 S.O. Ciurea et al. 162 Fig. 3 Immunophenotyping by mass cytometry with ...
Combined flow cytometry natural killer immunophenotyping and KIR/HLA-C genotyping reveal remarkable differences in acute myeloid leukemia patients, but suggest an overall impairment of the natural killer response[J]. Front Med (Lausanne), 2023,10:1148748. DOI: 10.3389/fmed.2023.1148748 . 返回引文...
To exclude T-cell type LGL leukemia and leukemic infiltration of other T-cell lymphomas, the tumor cells were required to be negative for surface CD3 as determined by flow cytometry or germline configurations of TCR genes. The presence of EBV was determined with either in situ hybridization with...
研究证实,T细胞免疫球蛋白黏蛋白分子3(T cell immunoglobulin mucin-3, Tim-3)、PD-1、CTLA-4等负性共刺激分子在介导肿瘤逃逸机制中扮演了关键角色 [ 1 ]。近年,Tim-3作为T细胞免疫球蛋白黏蛋白分子家族中一员 [ 2 ],参与肿瘤逃逸的机制成为研究的热点。负性共刺激分子Tim-3通过向肿瘤浸润组织中T细胞提供抑制...
Results from multivariable analysis showed that NK-cell admin- istration was associated with a significantly decreased risk of disease relapse vs. controls (HR of controls 13.76; 95% CI Leukemia (2022) 36:155 – 164 S.O. Ciurea et al. 162 Fig. 3 Immunophenotyping by mass cytometry with ...
this was described with a TCR-like CAR that was specific for a mutated nucleophosmin-1-derived neoepitope presented by HLA-A2 in an acute myeloid leukemia model [96]. Intracellular antigens are processed before being presented on the MHC cell surface. These peptides are then recognized by speci...
flow cytometry NK cell; natural killer cell; NK-like T-cell; acute myeloid leukemia; AML; myelodysplasia; myelodysplastic syndrome; MDS; 机译:流式细胞术NK细胞;自然杀伤细胞;NK样T细胞;急性髓细胞白血病;AML;骨髓增生异常;骨髓增生异常综合征;MDS; 入库时间 2022-08-18 09:50:04 相似文献 外文文...