The status of immune cells within human pancreatic lymphatic tissues during the onset and progression of type 1 diabetes (T1D) is underexplored. Here, by flow cytometry and CITEseq, the authors profile pancreatic, mesenteric, and splenic lymphatic tissues from individuals with varying clinical statuse...
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However, studies on CD56neg NK cells had revealed contradictions, probably due to the lack of a specific NK cell surface marker that helps to identify this subset. This protocol details the step-by-step procedure for the identification and functional analysis of CD56neg NK cells, providing an ...
In addition to CD56, NK cells can be further characterized into a variety of subsets through many different cell surface markers including CD16 and the KIR family of receptors. Check out these tools that can be used for NK cell analysis including flow cytom...
通过流式细胞术检测 CD41+NK 细胞比例,发现 HIV-1 初治患者体内血小板 - NK 细胞聚集体显著多于健康人,且在 CD4 计数 < 200 cells/μl 的重症患者中比例更高。相关性分析表明,聚集体数量与 CD4 计数(r=-0.4253,P<0.0001)及 CD4/CD8 比值(r=-0.2466,P=0.0264)呈负相关,但与病毒载量无显著关联。免疫荧...
In wildtype mice, this expansion is rather modest, as 40–50% of all NK cells express the Ly49H receptor (Dokun et al., 2001). Therefore, it is unclear if the same type of memory phenotype would develop without a substantial clonal expansion. While there are a few markers described to...
DS (Figs 3a,b) in a pattern reminiscent of the uropod of polarized cells in the absence of stroma, which is shown inFig. 3a(lower panel). Further, we observed accumulation of the uropod markers CD43 and moesin at the DS (Fig. 3c), suggesting the DS may be a uropod-derived structure...
Human NK Cells Expanded using the CellXVivo™ Kit Express NK Cell-specific Markers.Human NK cells were enriched from peripheral blood mononuclear cells and expanded (3 x 106starting population) using the CellXVivo™NK Cell Expansion Kit (A, C, E) or by the standard method using artificial...
体外扩增培养的nkinkt细胞及...前言 NK细胞（natural killer），即自然杀伤细胞,是机体固有免疫的组成细胞。NK细胞主要来源于骨髓，在骨髓微环境中逐渐发育成熟，分布至外周血中。当病毒感染细胞、寄生虫侵入等感染因素发生及自身细胞衰老、恶变时，NK细胞可以识别这些异常的细胞，通过穿孔素/颗粒酶途径直接裂解异常细胞...
synNotch-programmed iPSC-derived NK cells usurp TIGIT and CD73 activities for glioblastoma therapy Kyle B. Lupo, Xue Yao, Shambhavi Borde, Jiao Wang, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, MacKenzie McIntosh & Sandro Matosevic Nature Communic...