Nigericin 通过降低细胞内 pH (pHi) 和 Wnt/β-catenin 通路信号而显示出良好的抗癌活性。Nigericin 在 TNBC 中通过 caspase 1/GSDMD 途径诱导细胞焦亡 (pyroptosis)[3] 。 生物活性:Nigericin 是一种抗生素,源自吸水链霉菌,作为K+/H+离子载体< /b>,促进 K+/H+? 跨线粒体膜交换[1]。Nigericin can be a...
Pyroptosis provides a new window for relieving the tumor immunosuppressive microenvironment(TIM)and promoting systemic immune responses for tumor treatments.However,gasdermin D(GSDMD),a key protein in the pyroptosis process mediated by caspase-1,is low expressed in the majority of tumor cells and small...
The combination of MRS2211 and nigericin can eliminate the inhibition of MRS2211 on pyroptosis and counteract the activation of NLRP3 by nigericin. All data were expressed as mean ± SEM (n = 3/group).*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Show more...
In a recent study, nigericin was also used to induce pyroptosis in mouse bone marrow-derived macrophages (iBMDM) and mouse microglia (BV2) [22]. View article Review article Evidence of nigericin as a potential therapeutic candidate for cancers: A review Biomedicine & Pharmacotherapy Journal2021, ...
2.Luo R, Hu Y, Wang L, et al.Penthorum chinense Pursh extract ameliorates hepatic steatosis by suppressing pyroptosis via the NLRP3/Caspase‐1/GSDMD pathway.Food Science & Nutrition.20243.Li X, Li X, Xiang C, et al.Starvation-induced phosphorylation activates gasdermin A to initiate ...
Nigericin has been reported to induce apoptosis and pyroptosis in mammalian models. However, the effects and mechanism underlying the immune responses of teleost HKLs induced by nigericin remain enigmatic. To decipher the mechanism after nigericin treatment, the transcriptomic profile of goldfish HKLs wa...
(NLR); Bacterial; Antibiotic; Pyroptosis; Wnt; β-catenin作⽤通路: Membrane Transporter/Ion Channel; Immunology/Inflammation; Anti-infection; Apoptosis; Stem Cell/Wnt储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis.BIOLOGICAL ACTIVITY⽣物活性...
Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome-dependent pyroptosis Background Coronary microembolization (CME), a common reason for periprocedural myocardial infarction (PMI) after coronary interventions, bears very import... A Chen,ZW Chen,...
Here, we demonstrated that the antibiotic nigericin caused TNBC cell death by inducing concurrent Caspase-1/GSDMD-mediated pyroptosis and Caspase-3-mediated apoptosis. Notably, we found that nigericin-induced pyroptosis promoted the infiltration and activation of T cells, as well as showing a ...
(4) Finally, inflammasome formation leads to the processing and activation of caspase-1, which cleaves the pro-forms of IL-1β and IL-18, resulting in the release of the mature cytokines and inducing cell death by pyroptosis.Figure adapted from Haneklaus et al., 2013.44 The NLRP3 ...