6H). The above results suggest that TMP@Alg-PBA/PVA effectively inhibits cell pyroptosis. 3.7. Underlying mechanism through which TMP@Alg-PBA/PVA suppresses pyroptosis Although the anti-pyroptotic properties of the TMP@Alg-PBA/PVA hydrogel were verified, the specific intracellular mechanism remained...
Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathwaysVPAIschemic/reperfusionPyroptosisARCIschemic stroke is the third most common cause of death and the leading cause of disability worldwide in adults. The antiepileptic drug valproic acid (VPA) was ...
Pyroptosis is proinflammatory, but its effect on antitumour immunity is unknown. Here we establish a bioorthogonal chemical system, in which a cancer-imaging probe phenylalanine trifluoroborate (Phe-BF3) that can enter cells desilylates and ‘cleaves’ a designed linker that contains a silyl ether...
Besides, the potential role of tumor cell pyroptosis in enhancing anti-PD-1/PD-L1 ICB treatment efficiency and our perspective for application have also been discussed. 2. Tumor immunotherapy and its current challenge The “cancer-immunity cycle” is the main way in which our immune system ...
Pyroptosis in anti-bacteria immunity: sensing and execution Inflammatory caspases including caspase-1,4,5 and 11 are critical for cytosolic defences against bacterial infections.Caspase-1 is activated by canonical inflammasomes that sense diverse bacterial infections.We identify the NAIP family o... F...
As a phenolic compound extracted from grapes, piceatannol (PIC) exhibits anti-cancer properties. To the best of our knowledge, however, the effects of PIC on UM have not been well investigated. Therefore, in the present study, considering the impact of pyroptosis on modulating cell viability, ...
sensitize 4T1tumourstoanti-PD1therapy.Ourbioorthogona systembase on Phe-BF 3 esi y ationisthere oreapower u too orchemica bio ogy;ourapp ication o thissystemsuggeststhatpyroptosis-in uce in ammationtriggersrobust antitumourimmunityan cansynergizewithcheckpointb ocka e. ...
Additionally, SHP2 knockdown augments tumor sensitivity to anti-PD-1 therapy, thus reinforcing the pro-pyroptotic effects and inhibiting tumor growth. In summary, our findings elucidate the mechanism by which SHP2 governs TNBC pyroptosis, underscoring the potential of SHP2 inhibition to suppress ...
(Schisandraceae) Fructus, has various pharmacological activities including anti-cancer effects. The purpose of this study was to investigate the effect of NK cells on Sch B's regulation of pyroptosis in HCC cells and the molecular mechanisms implicated. The results showed that Sch B alone could ...
Mechanistically, GSDME may mediate paclitaxel and doxorubicin-induced pyroptosis in breast cancer cells through the caspase-9/caspase-3 pathway, activate anti-tumor immunity, and promote the efficacy of paclitaxel and anthracycline-based neoadjuvant chemotherapy. This study has practical guiding significance...