associated with pyroptosis in CRC,and based on these DEGs,all CRC patients could be classified into two subtypes.Using Cox regression analysis,we analyzed the prognostic value of all pyroptosis-associated genes in the TCGA database and constructed a 15-gene model and divided all CRC patients in ...
Integrated analysis of single-cell RNA sequencing and bulk transcriptome data identifies a pyroptosis-associated diagnostic model for Parkinson’s disease Lin Wang, Yidan Qin, Jia Song, Jing Xu, Wei Quan, Hang Su, Huibin Zeng, Jian Zhang, Jia Li & Jiajun Chen Scientific Reports ...
We also performed functional enrichment analysis of PRGs, which revealed that these 33 PRGs were mainly involved in the regulation of the inflammatory response, pyroptosis, NOD-like receptor signalling pathway, TNF signalling pathway, Toll-like receptor signalling pathway, and apoptosis. Interestingly, t...
Immune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear. Here, we show that gasdermin-E (GSDME), a gasdermin family member, drives ICI-induced myocarditis. Pyroptosis mediated by GSDME, but not the canonical GSDMD...
Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we generate ApoE and GSDME dual deficiency mice. As
A proposed mechanism of action for HMGB1 in pyroptosis-induced blood brain barrier breakdown in DM-associated cognitive decline DM has long been associated with chronic low-grade inflammation. Given the importance of HMGB1 in the inflammatory response, recent interest has turned to the role of HMGB1...
A proposed mechanism of action for HMGB1 in pyroptosis-induced blood brain barrier breakdown in DM-associated cognitive decline DM has long been associated with chronic low-grade inflammation. Given the importance of HMGB1 in the inflammatory response, recent interest has turned to the role of HMGB1...
Pyroptosis mediated by GSDME, but not the canonical GSDMD, is activated in myocardial tissue of mice and cancer patients with ICI-induced myocarditis. Deficiency of GSDME in male mice alleviates ICI-induced cardiac infiltration of T cells, macrophages, and monocytes, as well as mitochondrial damage...
Pyroptosis and inflamm-aging have been newly identified to be involved in diabetic periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in periodontal inflamm-aging by impacting the senescence of fibroblasts, as well as the potential mechanism via NLR family CARD doma...
The mechanism of spinal cord injury (SCI) is highly complex, and an increasing number of studies have indicated the involvement of pyroptosis in the physiological and pathological processes of secondary SCI. However, there is limited bioinformatics research on pyroptosis-related genes (PRGs) in SCI....