Pyroptosis is an inflammatory form of cell death that activates the immune system. In keeping with this, several lines of evidence suggest that gasdermins (which form membrane pores in pyroptosis) might function
Pyroptosis heats anticancer immunity. ‘Cold tumor’: tumor cells create an immune tolerant microenvironment and avoid immune detection and killing by recruiting immunosuppressive cells, increasing immune checkpoint proteins, impeding antigen presentation, and releasing immune inhibitory factors. ‘Warming tumor...
Pyroptosis heats tumour immunityTwo studies published in Nature report that gasdermin-mediated pyroptosis of tumour cells induces cytotoxic lymphocyte-mediated antitumour immune responses.doi:10.1038/s41577-020-0297-2Kirsty MintonNature reviews. Immunology...