We demonstrate that the electrogenic transfer of ICD effector-encoding plasmids into mouse melanoma tumors when combined with intratumoral expression of cytokines IL-1尾, IL-12, or IL-18, enhanced anti-tumor imm
Pyroptosis is an inflammatory form of programmed cell death that is emerging as an important regulator of anti-tumor immunity and a potential therapeutic target. This review has summarized current knowledge on the molecular pathways of pyroptosis, its complex and dual role in ovarian cancer ...
PTEN Family in Tumor Development 50分钟 2882播放 Targeting protein neddylation and Cullin-RING ligase-5 for anti-cancer therapy 1时8分 2267播放 抗肿瘤新药研究三十年 1时2分 5628播放 The Emerging Role of CRL4 in Cancer Chemoresistance 1时3分 1446播放 TGF-β regulation of T regulatory cells in...
Previous studies have shown that GSDME is capable of activating anti-tumor immunity mediated by NK cells (Tan et al., 2022a). Additionally, GSDME could increase the numbers and function of NK cells, which would release granzyme B to cleave GSDME directly and activate caspase 3-independent ...
A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity. Angew. Chem. Int. Ed. Engl. 61, e202115800 (2021). Xie, C. et al. Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a...
Cytokines also play a key role in enhancing tumor immunity. Met supplementation might restore anti-tumor immunity by stimulating the secretion of IL-2, TNF-a, and IFN-r from TILs [182]. A study shows that NLRP3-dependent pyroptosis, induced by ChS-Ce6 nanovesicles in combination with laser...
This remodeled the tumor microenvironment and turned immunologically "cold" tumors into "hot" tumors, thereby sensitized these tumors to checkpoint blockade. Finally, the combination therapy of VSV-CHIKV and an immune checkpoint inhibitor (anti-PD-1) prolonged the survival of mice. In conclusion, ...
GSDME activation can also mediate anti-microbial immunity. Infections with VSV-1 or HSV-1 activate intrinsic apoptosis, which in keratinocytes results in GSDME-dependent pyroptosis that releases IL-1α and restricts infection.118Similarly, induction of extrinsic apoptosis, induced byYersiniainfections, ...
Recently, Zhang et al. demonstrated that GSDME can induce pyroptosis in tumor cells, thereby activating anti-tumor immunity by enhancing T cell-mediated responses [16]. In the realm of tumor immunotherapy, chimeric antigen receptor T cell (CAR-T) therapy has achieved remarkable success, particularl...
Immune cells not only respond directly to bacterial infection but are also influenced by the pyroptotic secretome released by other cells. The pyroptotic secretome, which includes cytokines and chemokines, can influence immune cell composition and proportions to exert proinflammatory or anti-inflammatory...