Innate immunityPyroptosis is a form of lytic, programmed cell death that functions as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, including viruses. This typ
82 This corresponds to the results obtained by Negash et al., who additionally identified Kupffer cells as the main source of IL-1β secretion in response to HCV.83 A further study revealed that HCV-activated monocytes contribute to IFN-γ production and antiviral activity of NK cells due to...
Knockdown of Sirtuin 1 enhances the inflammasome-mediated pyroptosis and cellular antiviral immunity by weakening the NF-κB-driven transcriptional repression of the AIM2 gene.45 Other inflammasomes Vrentas et al found that in different species, Bacillus anthracis lethal toxin (LT) could activate NLR...
Molecular and structural basis of DNA sensors in antiviral innate immunity. Front Immunol. 2020;11:613039. Corrales L, Woo S-R, Williams JB, McWhirter SM, Gajewski TF. Antagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA. J Immunol. 2016;196:3191. ...
to trigger pyroptosis, and GSDMB has tissue-specific expression and is highly upregulated by interferon-γ in epithelial tumor cells [121]. Furthermore, cytotoxic lymphocyte-mediated immunity is dependent on granzymes, which can enhance antitumor immunity and may be a potential candidate targeted ...
(Fig.1). Caspases, a class of cysteine proteases widely expressed in mammals, are mainly associated with programmed cell death and inflammatory responses, some of which play a key role in antiviral immunity. Among them, Caspase-1, Caspase-4, Caspase-5 and Caspase-11 have proved to dominate ...
Given the importance of this crosstalk network of cGAS-STING, inflammasomes and pyroptosis in the regulation of innate immunity, it is emerging as a new avenue to explore the mechanisms of multiple disease pathogenesis. Therefore, efforts to define strategies to selectively modulate cGAS-STING, ...
Pyroptosis is a notably inflammatory form of lytic PCD which has a key role in innate immunity and tumor development [34,43,44]. The term “pyroptosis” was initially proposed by Cookson and Brennan in 2001 to characterize this distinct process [45]. Originating from Greek roots, “pyroptosis...
The nano-prodrug promoted the release of danger-associated molecular patterns via inducing GSDME-related tumor cell pyroptosis, which then initiated adaptive immunity, boosted the efficiency of the immune checkpoint block- ade, achieved tumor regression, generated immuno- logical memory, and prevented ...
Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptos