Antimetastatic Effects of Gambogic Acid are Mediated via the Actin Cytoskeleton and NF-κB Pathways in SK-HEP1 Cells doi:10.1002/ddr.21249actin cytoskeletongambogic acidhepatocellular carcinomametastasisNF-κBHepatocellular carcinoma (HCC) is one of the most malignant and frequent cancers with a high ...
Crosstalk in NF-[kappa]B signaling pathwaysOeckinghausHaydenGhosh
Increased density of nerves and thickness of nerve bundles has been observed histologically in pancreatic ductal adenocarcinoma.7,8 In addition to the growth of nerves within the pancreatic tumor, these signals activate proliferative signaling pathways in the tumor and have been shown to increase ...
As a human pathogen, KSHV has evolved to interact with many cellular signaling pathways, especially those involved in control of infection and inflammation. Primary among these pathways is that which leads to the activation of the transcription factor, Nuclear Factor Kappa B (NFκB). NFκB is a...
Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways Jang M, Cho IH: Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and ...
NF-κB signaling pathways in mammalian and insect innate immunity NF-kappa BSignal Transduction昆虫NF-κB信号传递In this review, we discuss recent advances in understanding the signaling pathways in mammalian and Drosophila ... NS Silverman,T Maniatis - 《Genes & Development》 被引量: 2415发表: ...
changes in profile gene expression of important pathways occur. These alterations are in part mediated by ROS production. Therefore, our results reinforce the importance in understanding the mechanism by which RA induces neuronal differentiation in SH-SY5Y cells, principally due this model being commonly...
Multiple pathways contribute to platelet activation and NF-kappa B is a common pathway in this activation. Therefore, in platelet activation the modulation of NF-kappa B pathway could be a potential new target in the treatment of inflammation-related vascular disease therapy (antiplatelet and ...
Here, we show clearly that two degradation pathways control the level of IkappaBalpha. Free IkappaBalpha degradation is not controlled by IKK or ubiquitination but intrinsically, by the C-terminal sequence known as the PEST domain. NF-kappaB binding to IkappaBalpha masks the PEST domain from...
the protective mechanisms depend on the inhibition of S1PR2 on acinar cells and macrophages, which altered the early activation of inflammatory pathways, including NF-κB activation in the acinar cells, decreased peritoneal macrophage recruitment and regulated the M1 phenotype polarization of macrophages....