The canonical and non-canonical NF-κB pathways and their crosstalk: A comparative study based on Petri netsKira Tares a bJ¨org Ackermann cIna Koch c
B cellsAUTOPHAGYINFLAMMATORY bowel diseasesAUTOIMMUNE diseasesAutophagy is a regulated intracellular catabolic process by which invading pathogens, damaged organelles, aggregated proteins, and other macromolecules are degraded in lysosomes. It has been widely appreciated that autophagic activ...
Canonical and non-canonical Wnt pathways are involved in the genesis of multiple tumors; however, their role in pituitary tumorigenesis is mostly unknown. This study evaluated gene and protein expression of Wnt pathways in pituitary tumors and whether these expression correlate to clinical outcome. Gen...
Wnt signaling through canonical and non-canonical pathways: Recent progress The Wntbeta-catenin pathway regulates cell adhesion, morphology, proliferation, migration and structural remodeling. The aspects of the canonical and non-c... Widelitz,Randall - 《Growth Factors》 被引量: 466发表: 2005年 Xe...
Non-canonical NF-[kappa]B signaling pathway. Cell Res The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on the inducible processing of p100, a molecule functioning as both the p...
NF-κB Signaling Pathway Nuclear factor kappa B (NF-κB) is a TF that plays a key role in numerous signaling cascades that modulate several cellular processes, such as cell growth, survival, development, and inflammatory and immune responses. In mammals, five different kinds of NF-κB has bee...
Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, Box 902, Houston, TX 77030, USA The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex...
NIK signaling is a highly sought after target in many cancers15, and therefore defining the physiological relevance of non-canonical NFκB pathways is crucial. The role of non-canonical NFκB signaling in intestinal homeostasis still remain unclear. Here we show that intestinal epithelial NIK is ...
An overview of the currently known mechanisms involved in non-canonical TRAIL signaling and the subsequent activation of various kinases is provided. These kinases include RIP1, I kappa B/NF-kappa B, MAPK p38, JNK, ERK1/2, MAP3K TAK1, PKC, PI3K/Akt and Src. The functional consequences ...
Metalloprotease type III effectors that specifically cleave JNK and NF-κB Two major arms of the inflammatory response are the NF-魏B and c-Jun N-terminal kinase (JNK) pathways. Here, we show that enteropathogenic Escherichia coli... Kobi,Baruch,Lihi,... - 《Embo Journal》 被引量: 229发...