Tieu, B. C.Choudhary, S.Brasier, A. R.Denner, L. A.Tilton, R. G.DiabetesStarkey, JM, Haidacher, SJ, LeJeune, WS (2006) Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in
Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, Box 902, Houston, TX 77030, USA The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex...
In the non-canonical pathway, new Figure 2 The NFκB signaling module consisting of canonical and non-canonical pathways. The non-canonical pathway is activated through developmental signals activating NIK/IKK1. This activation results in the degradation of IκBδ and process- ing of p100 and ...
NF-κB Signaling Pathway Nuclear factor kappa B(NF-κB) is a TF that plays a key role in numerous signaling cascades that modulate several cellular processes, such as cell growth, survival, development, and inflammatory and immune responses. In mammals, five different kinds of NF-κB has been...
Non-canonical NF-κB signaling is elicited by TNFR subfamily members such as CD40, lymphotoxin-β receptor (LTβR) and B-cell activating factor receptor (BAFF-R), with specific functions in lymphoid organ development and B cell survival [2], [4]. At the molecular level, the non-canonical...
pathway reduced by 80% TWEAK pro-calcific properties and decreased osteogenic transition, TNAP and MMP9 activity. Blockade of non-canonical NFκB signaling by a siRNA targeting RelB reduced by 20% TWEAK pro-calcific effects and decreased TWEAK-induced loss of h-VSMCs contractile phenotype and ...
Previous research has linked the canonical NF-κB pathway to the non-canonical BMP pathway via the formation of the XIAP-Tab1-Tak1 complex [2, 3, 6–8]. Adapter proteins play a pivotal role in the regulation and function of signal transduction pathways. Activation of NF-κB pathways ...
Thus, while the NEMO CC2, UBAN and ZF in the C-terminus are essential for TNFα signaling, these domains are largely dispensable for IL-1β signaling, empha- sizing that distinct NEMO surfaces are required for bridging the different receptor pathways to canonical NF-κ B. pUSucobotb...
NIK signaling is a highly sought after target in many cancers15, and therefore defining the physiological relevance of non-canonical NFκB pathways is crucial. The role of non-canonical NFκB signaling in intestinal homeostasis still remain unclear. Here we show that intestinal epithelial NIK is ...
It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of physiological osteoclast differentiation. However, the specific drivers and mechanisms driving inflammatory osteoclast differentiation under pathological conditions remain obscure. This is especially true given that infl...