40.Non-Canonical NF-kB Signaling Pathway是细胞信号通路 教学讲解的第40集视频,该合集共计51集,视频收藏或关注UP主,及时了解更多相关视频内容。
Meyerovich K, Fukaya M, Terra LF, Ortis F, Eizirik DL, Cardozo AK. The non-canonical NF-kappaB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro. Diabetologia. 2015....
The non-canonical NF-κB pathway is tightly controlled by ubiquitin-dependent degradation of NIK mediated by an E3 ubiquitin ligase complex composed of cIAP family members, TNFR-associated factor 2 (TRAF2) and TRAF3; activation of non-canonical NF-κB involves signal-induced disruption of the cIA...
Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, Box 902, Houston, TX 77030, USA The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex...
The non-canonical NF-κB pathway is crucial for the immune system. A critical event in activation of the non-canonical pathway is the attenuation of NF-κB-inducing kinase (NIK) degradation, which is promoted by continuous polyubiquitination of NIK catalyzed by the NIK ubiquitin-ligase complex co...
A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny 喜欢 0 阅读量: 7 作者: LM Wackerbarth,I Rohwedder,K Heinig,A Ballweg,J Altsttter,M Ripphahn,C Nussbaum,M Salvermoser,S Bierschenk,T Straub 展开 DOI: 10.1055/s-0043-1769253 ...
Silencing by a specific siRNA of NIK, the upstream kinase of the non-canonical NFκB pathway, prevented CCL21 upregulation but did not modulate CCL19 or RANTES expression in response to TWEAK, thus establishing CCL21 as a non-canonical NFκB target in podocytes. Increased kidney Fn14 and ...
Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis. The former is dependent on the I...
Interleukin-17A (IL-17A) is a newly emerging player in the pathogenesis of chronic lung diseases that amplifies inflammatory responses and promotes tissue remodeling. Stimulation of lung epithelial cells with IL-17A leads to activation of the transcription factor, nuclear factor kappa B (NF-κB), ...
We wanted to determine if NRAGE was also required for the activation of NF-κB through the non-canonical BMP pathway. Overexpression of full length NRAGE in 293HEK cells resulted in the constitutive phosphorylation of IKK-α and IKK-β (Figure 1A) while disruption of NRAGE expression through ...