It was suggested that Cyr61/NF-kB signaling pathway mediates the upregulation of IL-8 in response to cyclic stretch in A594 cells. These findings support the hypothesis that Cyr61 plays a critical role in acute lung inflammation triggered by mechanical strain.Yan ZHANG...
Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for...
Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for...
3.2. I-BET’s Effect on Protecting β-Cells from Cytokine-Mediated Apoptosis Is Mediated by Antagonizing the NF-kB Signaling Pathway NF-κB is one of the major pathways responsible for inflammation-induced apoptosis of pancreatic β-cells [41,42], and inhibiting this could provide a therapeutic...
The ubiquitous PI3K/Akt pathway regulates proliferation, apoptosis and differentiation by controlling a broad range of target proteins including NF-kappa B and GSK-3 beta. The roles of the PI3K/Akt/ NF-kappa B and PI3K/Akt/GSK-3 beta pathways in CPB-related lung injury are unclear.关键词:...
IkB kinases: key regulators of the NF-kB pathway The nuclear factor (NF)-κB pathway is important for the expression of a wide variety of genes that are involved in the control of the host immune and inflammatory response, and in the regulation of cellular proliferation and survival. T......
et al. Polyhydroxylated Metallofullerenols Stimulate IL-1 beta Secretion of Macrophage through TLRs/MyD88/NF- kappa B Pathway and NLRP3 Inflammasome Activation. Small 10, 2362-2372, doi: 10.1002/smll.201302825 (2014).Chen Z, Liu Y, Sun B, Li H, Dong J, Zhang L, et al. Poly...
In addition, Q-3-G increased the phosphorylation of c-Jun, Jun N-terminal kinase (JNK), Mitogen-activated protein kinase (MAPK) kinase 4 (MKK4), and TAK1, involved in the MAPKs/AP-1 pathway, and the phosphorylation of IκBα, IκB kinase (IKK)-α, Akt, and Src, involved in ...
The induction of IL-1β is reported to be regulated by the NF-κB-activated signaling pathway [52]. On the other hand, IL-1β has been documented to increase the activity of NF-κB once activated [53,54]. In the present study, we observed that CL (200 and 400 mg/kg) suppressed ...
The results indicate that LPS activation of a NF-κB pathway enhances TGFβ1-induced PDGF-B expression in BDECs.doi:10.1096/fasebj.25.1_supplement.1018.14Karen M. KasselBradley P. SullivanJames P. Luyendykfaseb journal