Involvement of RAGE, MAPK and NF-kappaB pathways in AGEs-induced MMP-9 activation in HaCaT keratinocytes. Exp Dermatol 2012;2: 123-129.Zhu P,Ren M,Yang C,et al.Involvement of RAGE,MAPK and NF-kappaB pathways in AGEs-induced MMP-9activation in HaCaT keratinocytes. Experimental Dermatology ....
demonstrated that SCP3 induced macrophages activation and enhanced TNF-α and NO production via TLR4-mediated MAPK and NF-κB pathways. In summary, SCP3 has significant immunomodulatory potential. The underlying molecular ...
demonstrated that SCP3 induced macrophages activation and enhanced TNF-α and NO production via TLR4-mediated MAPK and NF-κB pathways. In summary, SCP3 has significant immunomodulatory potential. The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS ...
The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B (NF-κB) and ...
to downregulate the nuclear factor-kappa B (NF-κB)-dependent inflammatory response via direct suppression of the phosphorylated-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IκBα) degradation and downregulation of the p65 unit of activated NF-κB [25]....
Similarly, NF-κB inhibition using BAY 11-7082 decreased p65 phosphorylation and IL-6 secretion but increased the concentration of IκBα. These findings reveal significant roles for the p38 and NF-κB signaling pathways in IL-6 secretion induced by CCF in MLO-Y4 cells. 展开 ...
Recent studies show that mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) signaling pathways are two pivotal roles contributing to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI). The present study aimed to investigate the protective effect ...
首次探究了丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、蛋白激酶B(protein kinase B,AKT)和核因子κB(nuclear factor kappa B,NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制,并分别从...
Moreover, it mediaes its signal transduction via MAPK and NF-κB pathways and revives the levels of mir-34a and mir-93. These findings are valuable for the anti-inflammatory effects of this new compound with particular reference to microRNA involvement in the ginseng family. 1. Introduction ...
In addition, L-THP can inhibit the ERK/nuclear factor- kappa B (NF-κB) signaling pathway, thereby inhibiting the apoptosis and autophagy of hepatocytes. The protective effect of L-THP has been shown to be positively correlated with its dose.78 Wang et al used a HIRI model in mice to ...