This study was designed to evaluate the antitumor activity of low-molecular-weight β-glucan (LMBG) produced by gamma irradiation (50 kGy), using in vivo and in vitro models.RESULTSThe results indicate that treatment with LMBG increased the proliferation of murine peritoneal macrophages, and their...
Apoptosis levels were substantially higher (5- to 10-fold) when active YopJ was delivered into macrophages expressing IkappaBalpha superrepressor or A20, suggesting that deactivation of the NF-kappaB pathway is not sufficient for rapid Yersinia-induced apoptosis. When macrophages expressing A20 were ...
demonstrated that SCP3 induced macrophages activation and enhanced TNF-α and NO production via TLR4-mediated MAPK and NF-κB pathways. In summary, SCP3 has significant immunomodulatory potential. The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS ...
demonstrated that SCP3 induced macrophages activation and enhanced TNF-α and NO production via TLR4-mediated MAPK and NF-κB pathways. In summary, SCP3 has significant immunomodulatory potential. The underlying molecular ...
The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B (NF-κB) and ...
Similarly, NF-κB inhibition using BAY 11-7082 decreased p65 phosphorylation and IL-6 secretion but increased the concentration of IκBα. These findings reveal significant roles for the p38 and NF-κB signaling pathways in IL-6 secretion induced by CCF in MLO-Y4 cells. 展开 ...
kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Therefore, the phenolic extract fromC. speciosais a desirable anti-inflammatory agent for inflammatory conditions to meet the rising demand for natural and cost-effective therapeutics....
The results showed that QFAE restrained mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways in LPS-induced RAW 264.7 cells, whereas AMP-activated protein kinase (AMPK) signaling pathways were activated, as revealed by prominent attenuation of phosphorylation...
首次探究了丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、蛋白激酶B(protein kinase B,AKT)和核因子κB(nuclear factor kappa B,NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制,并分别从...
and nuclear factor kappa B(NF-κB) pathways play a significant role in the metabolic imbalance.Therefore,to study these signaling pathways provides a novel direction for understanding the causes and the treatment of IDD.This article summarizes MAPK and NF-κB signal transduction pathways and their ...