HaCaT cells receiving neither pretreatment nor stimulation served as blank control, untreated HaCaT cells stimulated by rhTNF-α as stimulator control, and HaCaT cells pretreated with turmeric root tuber and stimulated by rhTNF-α as...
Interestingly, disruption of Hsp90/IKK association abolishes the recruitment of IKK to the tumor necrosis factor (TNF) receptor I (TNFR-I) and subsequent activation of IKK induced by TNF, a prototypic stimulator of the canonical NF-κB signaling [31]. Surpris- ingly, disruption of the Hsp90...
Because ROS are well-known as a stimulator of the transcription factor NF-κB33, we checked the effects of LCA and metformin on ROS production. We found that LCA strongly stimulated ROS production and that both metformin and NAC pretreatment completely negated the ROS stimulated by LCA (Fig. ...
A Correlation between PROS1 and 150 immunomodulators ((chemokine (41), receptor (18), MHC (21), Immunoinhibitor (24) and Immunostimulator (46)). B Correlation analysis between PROS1 expression in Pan-cancer and immune checkpoint gene expression. C–G Correlation of SEMA3F expression with ...
HaCaT cells receiving neither pretreatment nor stimulation served as blank control, untreated HaCaT cells stimulated by rhTNF-α as stimulator control, and HaCaT cells pretreated with turmeric root tuber and stimulated by rhTNF-α as positive control. Results From 0.39 to 1.56 μg/mL, both HB-...
Background Interleukin-6 (IL-6) is a potent stimulator of osteoclastic activity. Lipopolysaccharide (LPS) has been shown to regulate the expression of potent inflammatory factors, including TNF-alpha and IL-6. Currently, effective therapeutic treatments for bacteria-caused bone destruction are limited...
Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-jB. Eur J Pharmacol 2011; 650:451-7.Huang G, Yang Y, Xu Z, Zhou P, Gong W, Li Y, Fan J, He F: Downregulation of B lymphocyte stimulator expression by curcumin in...
Several systemic inflammatory stimulators (tumor necrosis factor [TNFalpha], lipopolysaccharide, thioglycollate, and carageenan) given to control mice showed that the inflammatory promotion of TF expression by only pulmonary vein endothelium is not specific to the sickle cell disease model. We bred ...
Together, these data indicate that acidic pH is a potent stimulator of IL-6 production in HET-1 cells and PKC plays a key role in the regulation of acidic pH mediated IL-6 upregulation via NFB activation and the acidic pH may represent analogous inflammatory response ....
While the pathophysiology of the NHL-B is still unclear, the need to identify the relevant genes and critical signaling pathways, and their involvement in the disease processes in NHL-B have begun to be elucidated. Recently, B Lymphocyte Stimulator (BLyS) has been described as a relatively new...