Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-κB. European Journal of Pharmacology, 650(1), pp.451-457.Guang Huang, Yanchun Yang, Zhizhen Xu, et al. Downregulation of B lymphocyte stimulator expression by curcumin in B...
Recently, B Lymphocyte Stimulator (BLyS) has been described as a relatively new member of the TNF ligand family, as a potent cell survival factor that is expressed in many hematopoietic cells, including neoplastic B cells. BLyS can bind to three receptors: TACI, BCMA, BAFF-R, and plays a...
et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263–266 (1999). 13 Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U., Guo, J., Horan, T. et al. T-cell co-stimulation through B7RP-1 and ICOS. ...
Interestingly, disruption of Hsp90/IKK association abolishes the recruitment of IKK to the tumor necrosis factor (TNF) receptor I (TNFR-I) and subsequent activation of IKK induced by TNF, a prototypic stimulator of the canonical NF-κB signaling [31]. Surpris- ingly, disruption of the Hsp90...
Correlation Between PROS1 expression and Immune checkpoint inhibitors and immunomodulators.ACorrelation between PROS1 and 150 immunomodulators ((chemokine (41), receptor (18), MHC (21), Immunoinhibitor (24) and Immunostimulator (46)).BCorrelation analysis between PROS1 expression in Pan-cancer and...
(cGAS) cytosolic DNA sensor, these cells express low levels of its adaptor protein, STING (stimulator of interferon genes, also known as MITA) [4]. A moderate IRF response is detected in HepG2-Dual™ cells upon incubation with STING agonists such as2’3’-cGAMP, while the3p-hpRNARIG-...
Several systemic inflammatory stimulators (tumor necrosis factor [TNFalpha], lipopolysaccharide, thioglycollate, and carageenan) given to control mice showed that the inflammatory promotion of TF expression by only pulmonary vein endothelium is not specific to the sickle cell disease model. We bred ...
These results demonstrate for the first time that LPA is a potent stimulator of IL-8 production in HBEpCs, which involves PKCδ/NF-κB signaling pathways.doi:doi:10.1074/jbc.M404045200Rhett CummingsYutong ZhaoDavid JacobyE. William Spannhake...
HaCaT cells receiving neither pretreatment nor stimulation served as blank control, untreated HaCaT cells stimulated by rhTNF-α as stimulator control, and HaCaT cells pretreated with turmeric root tuber and stimulated by rhTNF-α as positive control. Results From 0.39 to 1.56 μg/mL, both HB-...
Because ROS are well-known as a stimulator of the transcription factor NF-κB33, we checked the effects of LCA and metformin on ROS production. We found that LCA strongly stimulated ROS production and that both metformin and NAC pretreatment completely negated the ROS stimulated by LCA (Fig. ...