The noncanonical NF-κB pathway does not require the trimeric IKK complex or IκBα degradation but rather depends on the processing of theNfkb2gene product p100 [13,14] (Fig.2). P100 is the precursor protein of the NF-κB subunit p52, which contains a C-terminal portion that is homolog...
Here, we have described for the first time a pivotal role for c-Rel as a stimulator of cardiac hypertrophy and remodeling. Our data suggest that c-Rel is predominantly found in the cytoplasm of cardiomyocytes in the normal human heart, whereas its localization is primarily nuclear in the ...
Cytokines and other pathological factors produced during renal ischaemia–reperfusion injury are also strong stimulators of NF-κB. In particular, ischaemia–reperfusion induces the production of TNF-α in an NF-κB-dependent manner, and TNF-α in turn binds to its receptor to stimulate NF-κB ...
Previous investigation showed that HBoV infection could significantly upregulate the level of TNF-α which is a strong NF-κB stimulator. Here we investigated whether HBoV proteins modulate TNF-α–mediated activation of the NF-κB signaling pathway. We showed that HBoV NS1 and NS1-70 proteins ...
Previous investigation showed that HBoV infection could significantly upregulate the level of TNF-α which is a strong NF-κB stimulator. Here we investigated whether HBoV proteins modulate TNF-α–mediated activation of the NF-κB signaling pathway. We showed that HBoV NS1 and NS1-70 proteins ...
Misra1, Bharti Singh2,4, Aditi Mishra3,4 and Suraksha Agrawal2 Co-stimulatory CD28 and transcription factor NFKB1 genes are considered as a crucial player in the determination of inflammatory responses; genetic variability in these may modulate the risk for idiopathic recurrent miscarriages (IRM)....
Previously we have described a rat pain model in which localized inflammation of the DRG (LID) is induced by depositing a small drop of the immune stimulator zymosan over the L5 DRG. This leads to prolonged mechanical pain behaviors, and a rapid increase in levels of GRO/KC and other pro...
We assign a new role for the c-Rel subunit as a stimulator of cardiac hypertrophy and fibrosis. We discovered that c-Rel-deficient mice have smaller hearts at birth, as well as during adulthood, and are protected from developing cardiac hypertrophy and fibrosis after chronic angiotensin infusion...
Stimulator of interferon genes (STING) is an adaptor molecule that links sensing of cytosolic DNA to the production of IFNs and NF-κB. COVID-19 can cause damage to self-DNA and hyperactive STING resulting in IFN-beta release and a cytokine storm following IRF-3 and NF-κB activation [46...
The HTLV-I transforming protein Tax functions as an intracellular stimulator of IκB kinase (IKK), a cellular kinase mediating NF-κB activation by diverse stimuli. Tax physically interacts with IKK and renders this inducible kinase constitutively active. By assembling different Tax/IKK complexes, ...