This study was designed to evaluate the antitumor activity of low-molecular-weight β-glucan (LMBG) produced by gamma irradiation (50 kGy), using in vivo and in vitro models.RESULTSThe results indicate that treatment with LMBG increased the proliferation of murine peritoneal macrophages, and their...
Antimetastatic Effects of Gambogic Acid are Mediated via the Actin Cytoskeleton and NF-κB Pathways in SK-HEP1 Cells doi:10.1002/ddr.21249actin cytoskeletongambogic acidhepatocellular carcinomametastasisNF-κBHepatocellular carcinoma (HCC) is one of the most malignant and frequent cancers with a high ...
Quan Y, Jiang CT, Xue B, Zhu SG, Wang X (2011) High glucose stimulates TNFalpha and MCP-1 expression in rat microglia via ROS and NF-kappaB pathways. Acta Pharmacol Sin 32:188–193 CentralQuan Y, Jiang CT, Xue B, Zhu SG, Wang X (2011) High glucose stimulates TNFalpha and MCP-...
Increased density of nerves and thickness of nerve bundles has been observed histologically in pancreatic ductal adenocarcinoma.7,8 In addition to the growth of nerves within the pancreatic tumor, these signals activate proliferative signaling pathways in the tumor and have been shown to increase ...
Multiple pathways contribute to platelet activation and NF-kappa B is a common pathway in this activation. Therefore, in platelet activation the modulation of NF-kappa B pathway could be a potential new target in the treatment of inflammation-related vascular disease therapy (antiplatelet and ...
Other pathways, such as the JAK-STAT pathway, another pathway of interest involved in CAVD disease, are also affected by AGP [18]. Whether the disfunction of RELA induced a change in the STAT pathway or AGP directly acted on STAT, remains unclear. Based on the results of the analysis of...
Thrombin-stimulated endothelium synthesizes numerous adhesion molecules to recruit leukocytes; however, it is unknown which intracellular pathways are responsible for this event. A recent report from our laboratory has shown that thrombin induces E-selectin expression and that blocking nuclear factor-kappa...
NF-κB signaling pathways in mammalian and insect innate immunity NF-kappa BSignal Transduction昆虫NF-κB信号传递In this review, we discuss recent advances in understanding the signaling pathways in mammalian and Drosophila ... NS Silverman,T Maniatis - 《Genes & Development》 被引量: 2415发表: ...
Here, we show clearly that two degradation pathways control the level of IkappaBalpha. Free IkappaBalpha degradation is not controlled by IKK or ubiquitination but intrinsically, by the C-terminal sequence known as the PEST domain. NF-kappaB binding to IkappaBalpha masks the PEST domain from...
As a human pathogen, KSHV has evolved to interact with many cellular signaling pathways, especially those involved in control of infection and inflammation. Primary among these pathways is that which leads to the activation of the transcription factor, Nuclear Factor Kappa B (NFκB). NFκB is a...