The potential for off-target effects, impacting alternate signaling pathways or cellular functions, further complicates NF-κB inhibition. Moreover, AD’s heterogeneity, characterized by diverse underlying mechanisms and pathological manifestations, results in NF-κB potentially exerting differential impacts ...
NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res, 21, 55-70.Blonska M, Lin X. 2011. NF-B signaling pathways regulated by CARMA family of scaffold proteins. Cell Res 21:55-70. https://doi.org/10.1038/cr .2010.182....
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates dam... S Fulda - 《International Journal of Cell Biology》 被引量: 787发表: 2010年 Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its...
glia. Ammonia did not alter the levels of Egrs and TFAM in astroglia. Ammonia decreased OCR, ATP, COX, and OXPHOS levels in astroglia. To assess whether energy metabolism is reduced by ammonia through NF-κB associated pathways, astroglia were treated with ammonia alone or with NF-κB ...
DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-α-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-κB pathways in huma... DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced IL-8 and CCL20 production by inhibiting p38 kinase...
As activation of NF-κB pathways has been previously associated with poor prognosis, it is possible that members of the NF-κB pathways could serve as prognostic markers or novel therapeutic targets for CRC. Indeed, several suggestions for anti-NF-κB therapeutics for colon cancer treatment have ...
Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. The relationship between diabetes mellitus and pancreatic cancer is complex. Diabetes has been postulated to be both an independent risk factor and a con...
This approach can provide us with mathematically well-founded and tractable interpretations regarding pathways, especially those best described by enzyme reactions. This paper introduces not only an intuitive graphical model but also a quantitative mathematical model for the TNF mediated NF- B signaling ...
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF- kappa B Signaling Pathways 来自 掌桥科研 喜欢 0 阅读量: 23 作者: YZY Zeng 摘要: Britanin, a natural pseudoguaiacane sesquiterpene lactone, has significant antioxidant and anti-inflammatory ...
ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-κB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-κB downstream target genes TNF-α, ICAM-1, IL-2, and IL-6. Those effects were mediated directly or indirectly by SIRT6. We provided...