NF-kB's contribution to B cell fate decisions. Front Immunol. 2023 Jul 18;14:1214095. doi: 10.3389/fimmu.2023.1214095. PMID: 37533858; PMCID: PMC10391175.发布于 2024-02-20 17:18・IP 属地江苏 生物学 B细胞 NF-kB 赞同1添加评论 分享喜欢收藏申请转载 ...
Here we briefly discuss the role of NF-kB in regulating cell fate decisions at various times in the path of B cell development, activation, and the generation of long-term humoral immunity.Guldenpfennig, CaitlynTeixeiro, EmmaDaniels, Mark...
IKKα and ΙΚΚβ are best known for their roles in NF-κB activation, but NF-κB-independent functions have also been reported, some of which are even implicated in cell fate decisions (Hinz and Scheidereit, 2014). Using pharmacological inhibition of IKKα/IKKβ in a p65-deficient back...
As NF-κB and p53 can be activated by the same stimuli, the integration of both path- ways is critical for cell-fate 'decisions'. Competition between NF-κB and p53 for the histone acetyltransferases CBP and p300, which are required for transactivation by both factors, has been suggested as...
g NF-kB1 and Dll1 showed several open chromatin enriched peaks in Dll1+ tumor cells compared with Dll1− tumor cells. h–i Representative IHC images show higher nuclear NF-kB+ tumors cells in Dll1+ compared with Dll1− tumors. Cell sorting was performed to enrich for these population...
To address the contribution of JNK signaling to c-Jun phosphorylation, we used the adenosine triphosphate (ATP)–competitive inhibitor SP600125, which selectively interferes with JNK activity but not with the activity of a wide variety of other kinases.23 JNK was identified as a critical NF-κB...
Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells. The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not unde
references therein). The architecture of the genomic regions flanking theNF1gene in 17q11.2, characterised by low-copy repeats, predisposes to large deletions mediated by various different mutational mechanisms occurring in the germline of an unaffected parent or during mitotic postzygotic cell divisions...
The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood. Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically...
we computed several cell-specific quantitative features, most importantly: direct correlation is the Pearson correlation coefficient between the compound treatment and the gene KD expression signatures in the given cell line, and indirect correlation is the fraction of the KD protein’s interaction partne...