Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, ...
Cells are continuously exposed to various stress factors that endanger their functionality and thus, their ability to cope with stress. The ability of cells to adapt and survive by restoring homeostasis is an integral component of cellular physiology. However, if the stress is persistent and homeosta...
Zinovyev A, Fourquet S, Tournier L, Calzone L, Barillot E (2012) Cell death and life in cancer: mathematical modeling of cell fate decisions. Adv Expt Med Biol 736:261–274Zinovyev A, Fourquet S, Tournier L, Calzone L, Barillot E. Cell death and life in cancer: mathematical modeling...
& Graf, T. Transcription factors and 3D genome conformation in cell-fate decisions. Nature 569, 345–354 (2019). https://doi.org/10.1038/s41586-019-1182-7 Download citation Received15 October 2018 Accepted19 March 2019 Published15 May 2019 Issue Date16 May 2019 DOIhttps://doi.org/10.1038...
Resolving Cell Fate Decisions During Somatic Cell Reprogramming by Single-Cell RNA-Seqreprogramminginduced pluripotent stem cellssingle-cell RNA sequencing (RNA-seq)bifurcationcell fate decisionCell makes fate decision with intrinsic and extrinsic cues. It has been difficult to define the precise decision...
4. Limitations of Single-Cell Transcriptomics to Study Cell Fate Decisions 目前的计算方法很难去描述分子振荡和不对称细胞分裂在发育中的表现。 细胞分裂和技术上的批次效应会影响拟时间。 转录组只是一层的信息读数,还缺少其他的信息,比如表观等等。
dermal fibroblasts, and progenitors specific for these two cell types at E14.5 and E16.5. These enriched cell populations were then used for further culture and functional assays in vitro, in whichWnt5aandRgccare shown to be important factors that could alter lineage decisions during embryogenesis....
Bistable signaling motifs and cell fate decisions. In Quantitative Modeling in Toxicology (K. Krishnan and M. E. Andersen, Eds.). John Wiley & Sons, Hoboken, NJ.Bhattacharya, S., Zhang, Q., and Andersen, M. E. (2009). Bistable Signaling Motifs and Cell 37 Fate Decisions. In ...
Strikingly, a 1-min pulse of TNF can be more effective at killing than a 1-hour pulse, indicating that in addition to TNF concentration, duration of exposure also coordinates cell fate decisions. 展开 DOI: 10.1038/srep39519 被引量: 10 ...
during different phases of the preceding cell cycle, indicating direct cell cycle influences on both early lineage commitment and terminal cell fate decisions... Laura,JA Hardwick,Fahad,... - 《Cell & Tissue Research》 被引量: 43发表: 2015年 Genes at work in random bouts : Stochastically dis...