Cell fate specificationThe subdivision of mesodermal cells into muscle and non-muscle cells is crucial to animal development. In the C. elegans postembryonic mesoderm, this subdivision is a result of an asymmetric cell division that leads to the formation of striated body wall muscles and non-...
These preimplantation cell fate decisions rely on a combination of factors including cell polarity, position and cell–cell signalling and are influenced by the heterogeneity between early embryo cells. At the point of implantation, signalling events between the embryo and mother, and between the ...
Cell fate decisions and axis determination in the early mouse embryo. Development 139, 3–14 (2012). Article PubMed CAS Google Scholar Robertson, E. J. Dose-dependent Nodal/Smad signals pattern the early mouse embryo. Semin. Cell Dev. Biol. 32, 73–79 (2014). Article PubMed CAS ...
The spatial sorting of RNA transcripts is fundamental for the refinement of gene expression to distinct subcellular regions. Although, in non-mammalian early embryogenesis, differential RNA localisation presages cell fate determination, in mammals it rem
There is a long-running controversy about how early cell fate decisions are made in the developing mammalian embryo.11. Rossant J, Tam PPL. Blastocyst line... P Pantazis,T Bollenbach - 《Cell Cycle》 被引量: 16发表: 2014年 Decreased cofilin1 expression is important for compaction during ...
Up-to-date summary how transcription factors regulate cell fate decisions and maintenance of cell type memory. • Comprehensive summary of molecular roles of Otx2, Six3 and Six6 in the early retinal development. • Dissection of mouse, chicken, frog and zebrafish animal models. • Critical ...
Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial stages of embryo development. Among these factors, the Polycomb group (PcG) of proteins plays a key role in establishing correct transcriptional programmes during mo
Polarity in Cell-Fate Acquisition in the Early Mouse Embryo Establishing polarity is a fundamental part of embryogenesis and can be traced back to the earliest developmental stages. It can be achieved in one of two ... CY Leung,M Zhu,M Zernicka-Goetz - 《Current Topics in Developmental Biol...
This study provides a detailed analysis of the effects of perturbing DNA methylation on mouse organogenesis at a whole organism scale and affords new insights into the regulatory mechanisms of cell fate decisions. Background Early mammalian development is accompanied by epigenetic reprogramming. In the...
Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation. Cell Rep. 2017;20:1215–28. Article CAS PubMed PubMed Central Google Scholar Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, et al. Epigenomic analysis of gastrulation identifies ...