As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the ph
Developmentally, E12 mouse gut is just initiating midgut rotation and is similar to that of a midfirst trimester human embryo (26). Nutrient and oxygen diffusion in this model appears to be sufficient, because cytotoxic changes were not apparent during culture and the most intensely proliferative ...
1977 . The development of the conduction system in the mouse embryo heart: I, the first embryonic A-V conduction pathway . Dev Biol 56 : 382 – 396 .Viragh SE , Challice C . 1982 . The development of the conduction system in the mouse embryo heart . Dev Biol 89 : 25 – 40 ....
The advance opens up new avenues for studying how stem cells form various organs in the developing embryo and better understanding how certain mutations drive various developmental diseases. It also raises profound questions about whether other animals, including humans, might one day be cultured...
Briefly, the RDI is defined as the distance from the center of the embryo to the center of a cell's nucleus (see Materials and methods). This allowed us to construct lineage graphs tracking nuclear position over time from the 8-cell to 32-cell stages for each 8-cell and all of its ...
The "totipotent-like" stem cells created by UC Berkeley researchers, who reported their work this week in the journal Science, are able to generate not only all cell types within a developing embryo, but also cell types that facilitate nutrient exchange between the embryo and the mother. ...
The "totipotent-like" stem cells created by UC Berkeley researchers, who reported their work this week in the journal Science, are able to generate not only all cell types within a developing embryo, but also cell types that facilitate nutrient exchange between the embryo and the mother. ...
Highly dynamic regional expression patterns within the developing primitive gut Before this and other recent screens in the early mouse embryo [23–25, 46], there were very few markers available that were specific to the definitive endoderm. Two of these screens extended their design to isolate re...
Plas- ticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Develop- ment 2013; 140:562-572. 48 Hirasawa R, Chiba H, Kaneda M, et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints...
The results of embryologic manipulations and molecular genetic experiments suggest that otocyst precursor cells proceed through several rounds of lineage restriction that progressively specify subsets of cells as prosensory cells, and ultimately as either HCs or SCs (ref. 1). Fig. 1: Characterization ...