一项最新的研究中显示MM细胞以依赖PAD4的方式诱导NET的形成,促使肿瘤相关血栓形成和肿瘤转移。而且,在MM微环境中随着NF-kB信号的激活,BMSCs显示出一种炎症性表型。他们不仅分泌几种细胞因子,如APRIL、BAFF、IL-6和RANKL,在促MM细胞增殖中有着重要角色,也引...
Correlations Between T Cell Levels of NF-kB/p65 Protein and Variables of Disease Activity in SarcoidosisCopyright in the material you requested is held by the American College of Chest Physicians (unless otherwise noted). This email ability is provided as a courtesy, and by using it you agree...
BCMA是一种III型跨膜蛋白,属于肿瘤坏死因子受体(TNFR)家族,在B细胞成熟末期表达上调,尤其是在浆细胞上选择性表达,且在大多数多发性骨髓瘤细胞上高水平表达,但在幼稚B细胞、记忆B细胞及其他正常组织细胞上基本不表达。BCMA通过与B细胞活化因子(B cell activating factor,BAF)结合,激活NF-KB和MAPK/JNK通路调节长寿...
et al. A novel mutation in the Nfkb2 gene generates an NF-κB2 ‘super repressor’. J. Immunol. 179, 7514–7522 (2007). Article CAS PubMed Google Scholar Yu, J. et al. T cell-intrinsic function of the noncanonical NF-κB pathway in the regulation of GM-CSF expression and ...
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of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene...
Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene....
4. Falahzadeh et al (2015) The potential roles of actin in nucleus. Cell J. 17:7-14.赞一...
The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length...
NF-κB in T cells and causes early onset lethal multi-organ autoimmunity36. In that study, we sorted conventional T cells (Tconv) and Tregs based on CD4 and CD25 expression and found that constitutive NIK expression exerts cell-intrinsic effects on both T cell subsets that, in combination, ...