NF-kB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998;101:802-11.Iimuro Y, Nishiura T, Hellerbrand C, et al. NFkB pre- vents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998; 101:802-11....
摘要 Hostorganismsuse different innate immune mechanisms to defend against pathogenic infections, while tight control of innate immunity is essential for proper immune induction and balance. Here, we reported that apoptotic induction or caspase-3 overexpression caused dramatic reduction of differently trigger...
6.Tiwari, H.S., Misra, U.K., Kalita, J., Mishra, A. & Shukla, S. Oxidative stress and glutamate excitotoxicity contribute to apoptosis in cerebral venous sinus thrombosis. Neurochem Int 100, 91-96 (2016). 7.N...
尤其在细胞因子诱导的基因表达中起关键性的调控作用.NF—KB通过调节细胞因子, 趋化,生长因子,黏附分子及多种酶的基因表达,参与机体免疫调节和炎症反应,并在细胞增殖,分化及凋亡方面起关键作用.已有研究表明:NF—KB在类风湿性关节炎的滑膜细胞中广泛表达,与其调控的细胞因子一起积极参与了关节炎症及损伤反应等病理进程...
Inhibition of NF-kB Renders Cells more Vulnerable to Apoptosis Induced by Amyloid β Peptides. One of the mechanisms leading to neurodegeneration during Alzheimer's disease (AD) is amyloid β peptide neurotoxicity. In response to a variety of stress ... Cardoso,M S.,Oliveira,... - 《Free ...
1. NF-KB的概述1.1 NF-KB/Rel蛋白家族及结构在哺乳动物细胞中共有五种NF-B家族成员【3】,它们是原癌基因CRel、NFB1(p50p105)、NFB2(p52p100)、Re1A(p65)、RelB。这些蛋白都有一个大约由300个氨基酸组成的氨基末端,称为Rel同源区(Rel homogeneous domain,RHD)或NRD(NFBReldorsa1)。其RHD内含DN 3、A...
即nf kb 在接下来的十分钟我们要解决四个问题1什么是NFKB2他又有怎样的结构特征3在细胞中信号是如何进行传导的4对生命活动又有怎样的意义于1986年，Sen 等首次从鼠B淋巴细胞核提取物在信号通路子－KB（nuclear factor-kappa B,NF-KB)蛋白家族是一种多效性的转录因子，可以与多种基启动子部位的KB位点发生特异...
inhibition of nf-kb sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (vp16) or doxorubicin Inhibition of NF-kB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene - Arlt, Vorndamm, et al... A Arlt,J Vorndamm...
是激活NF—KB的因素之一,体内过氧化物的积累可 以激活NF-KB。同时在机体的老化过程中,存在着 细胞凋亡过程。NF—KB可能在细胞氧化压力与细胞 老化或凋亡之间起调控作用。最终的结果有两种, 一种是抗氧化压力基因的表达,抑制凋亡;一种是启 动揭亡相关基因的表达并通过免疫系统清除死亡的 ...