Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132(3):344-362.3. Christian F, Carmody RJ, et al. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. Published 2016 Mar 18.4. Hoesel
2. Staudt LM. Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol. 2010;2(6):a000109. doi:10.1101/cshperspect.a000109 3. Pradère JP, Hernandez C, Koppe C, Friedman RA, Luedde T, Schwabe RF. Negative ...
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Peptide sequence around phosphorylation site of serine 536 (F-S-S(p)-I-A) derived from Human NFκB-p65. 缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. 分子量 Calculated MW: 60 kDa; Observed MW: 65 kDa ...
Activation of NF-κB occurs according to specific and sequential phosphorylation of residues such as Ser32 and Ser36 of IκBa leading to proteasome-mediated degradation. Further, phosphorylation of Ser 276 on RelA/p65 allows its oligomerization and regulation of DNA-binding. NF-κB phosphorylation ...
Certain stimuli result in the phosphorylation, ubiquitination and subsequent degradation of IκB proteins thereby enabling translocation of NF-κB into the nucleus.3 The most common Rel/NF-κB dimer in mammals contains p50-RelA (p50/p65) heterodimers and is specifically called NF-κB. One of the...
大家好,我是Wu YQ。今天为大家介绍一篇近期发表在Cell Metabolism上关于高糖促进肿瘤细胞免疫逃逸的文章,题目是“Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IkBa”。文章的通讯作者为浙江大学医学院吕志明团队。
and IkBe. The various stimuli that activate NF-kB cause phosphorylation of IkB, which is followed by its ubiquitination and subsequent degradation. This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucl...
NF-kB 诱导激酶(NIK) 是激活非经典 NF-kB 通路所必需的,它调节免疫、发育和疾病的不同过程。 尽管最近的研究阐明了 NIK 在适应性免疫细胞和癌细胞代谢中的重要功能,但 NIK 在先天免疫细胞中代谢驱动的炎症反应中的作用仍不清楚。 在这项研究中,我们证明小鼠 NIK 缺陷的骨髓衍生巨噬细胞表现出线粒体依赖性代谢...
and IkBe.Upon activation, NF-kB activation is triggered by stimuli-induced phosphorylation of IkB proteins. Following this event, IkB undergoes ubiquitination and is subsequently degraded, releasing the nuclear localization signals (NLS) on NF-kB subunits. This allows the protein to transl...