p65 Thr505磷酸化负调控多种细胞功能,如增殖、迁移和自噬。Thr505突变将消除p65对肿瘤的抑制功能,导致p65具有促进肿瘤增值和存活的能力。 (Moles A, Butterworth JA, Sanchez A, et al. A RelA(p65) Thr505 phospho-site mutation reveals ...
NFKB3; RELA; TF65; Transcription factor p65; p65; NFkB SwissProt ID Q04206 基因ID 5970 免疫原 Peptide sequence around phosphorylation site of serine 536 (F-S-S(p)-I-A) derived from Human NFκB-p65. 缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH...
IKK 复合物的活化导致 NF-κB 抑制剂蛋白 IκBα 的磷酸化，最终导致其蛋白酶体降解，并使 NF-κB 二聚体，如 p50-RelA (p65) 释放并易位至细胞核驱动靶基因的转录。在许多情况下，NF-κB 二聚体激活靶基因需要其他转录因子的协助，包括 STAT、AP1 家族成员，p53，NRF2，IRFs 等。图 3. TNFR1 介导的 ...
免疫原KLH conjugated Synthesised phosphopeptide derived from human NFKBp65 around the phosphorylation site of Ser276 亚型IgG 纯化方法affinity purified by Protein A 储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件Store at -20 °C for one year. Avoid repeated fre...
(Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52. However, binding of TNF alpha to its cognate receptor phosphorylates IKK which in turn phosphorylates I kB allowing proteasomal degradation of I kB. Phosphorylation of p65 at ...
NFkB-p65 (Phospho-Ser529) antibody was raised against a peptide sequence around phosphorylation site of serine 529 (L-L-S (p) -G-D) derived from Human NFκB-p65. NFkB p65 (phospho Ser529) AntibodyKey Feature ClonalityPolyclonal Host SpeciesRabbit ...
免疫原 :KLH conjugated Synthesised acetylpeptide derived from human NFKBp65 around the phosphorylation site of Lys310:TF(Ac-K)SI 亚型:IgG 纯化方法 :affinity purified by Protein A 储存液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. ...
Immunogen: KLH conjugated SynthesisedAnti-Phospho-NFKB p65(Ser468)抗体phosphopeptide derived from human NFKBp65 around the phosphorylation site of Ser468. ● Predicted Molecular Weight: 61kDa. Storage: Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles). ...
Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is ...
Certain stimuli result in the phosphorylation, ubiquitination, and subsequent degradation of IκB proteins, thereby enabling translocation of NF-κB into the nucleus.3 The most common Rel/NF-κB dimer in mammals contains p50-RelA (p50/ p65) heterodimers and is specifically called NF-κB. One of...