Pathway/LibraryApoptosis Pathway Library; Diabetes Related Genes Library Gene SummaryThis gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD ...
Apoptosis: AGT, BCL2A1 (BCL-X), BCL2L1, BIRC3 (c-IAP1). Other Factors Involved in NFκB Pathway: Kinases: AKT1, MAP3K1, RAF1. Transcription Factors: ATF1, EGR1, ELK1, FOS, JUN, STAT1. Other Genes: CARD11, CASP1 (ICE), CASP8, CFLAR (CASPER), HMOX1, MALT1, PSIP1, ...
The presented data collectively suggest that chronic cadmium treatment may impact the mA level through influencing regulatory proteins, which could potentially trigger oxidative stress and apoptosis by regulating transcription factors such as NF-魏B and NRF2. In conclusion, our study provides a scientific...
NF-kB Signaling Pathway Nuclear factor kB (NF-kB) is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorigenesis, inflammation, and various autoimmune diseases. The activation of NF-kB is th...
Pathway/Library Apoptosis Pathway Library; Diabetes Related Genes Library Gene Summary This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 ...
Pathway/LibraryApoptosis Pathway Library; Diabetes Related Genes Library Gene SummaryThis gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD ...
NF-kB Signaling Pathway Nuclear factor kB (NF-k is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation of apoptosis, viral replication, tumorigenesis, inflammation, and various autoimmune diseases. The activation of NF-kB is thoug...
NF-kB acts as a central mediator of immune and inflammatory responses, and is involved in stress responses and regulation of cell proliferation and apoptosis. The respective NF-kB target genes allow the organism to respond effectively to these environmental changes. The classical NF-kB pathway is ...
Active NF-κB turns on the expression of genes that keep the cell proliferating and protect the cell from conditions that would otherwise cause its death through apoptosis mechanism. In tumor cells, NF-κB is active either due to mutations in genes encoding the NF-κB transcription factors ...
NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB is activated by various intra- and extracellular stimuli such as cytokines,...