tryptophan surrogatesMild transition-metal catalysed cross-couplings enable direct functionalisation of biocatalytically halogenated tryptophans with alkyl iodides, representing a new alternative for late-stage derivatisations of halogenated aromatic amino acids. Moreover, this strategy enables preparation of ...
Negishi Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents. Georg Manolikakes,Matthias A. Schade,Carmen Mun?oz Hern,ez,Herbert Mayr,Paul Knochel. Organic Letters . 2008Negishi cross-couplings of unsaturated halides bearing relatively acidic hydrogen ...
In this article, highly diastereoselective CNegishi cross-couplings of various cycloalkylzinc reagents with aryl halides are reported. In all cases, the thermodynamically most-stable stereoisomer was obtained. Remarkably, this diastereoselective coupling was successful not only for 1,2-substituted cyclic ...
Stereoselective Bromoboration of Acetylene with Boron Tribromide: Preparation and Cross-Coupling Reactions of ( Z )-Bromovinylboronates Their reactivityin a Negishi cross-coupling reaction was tested. An example of theone-pot reaction sequence of Negishi and Suzuki–Miyaura cross-couplingsfor synthesis ...
Heck and Akira Suzuki “for palladium-catalyzed cross couplings inorganic synthesis”. 【Negishi普渡大学教授。由于在有机合成中对钯催化偶联方面的研究和Richard F. Heck , Akira Suzuki共同获得了2010年的诺贝尔化学奖。】 2. Erdik, E. Tetrahedron 1992, 48, 9577-9648. (Review). 3. De Vos, E.;...
Palladium catalysts ensure that a broad pertinence for Negishi cross-coupling reaction, environmental sustainability, and cost concerns lead to the examination of other transition metal catalysts for Negishi cross-couplings; nickel has directed to the most impressive developments. Standard nickel complexes,...
The inhibitors were synthesized from a common, dihalogenated late‐stage building block using palladium catalysed Suzuki–Miyaura and Negishi cross‐couplings in high yields. Conveniently, the benzylic carbon could be deprotonated using LiHMDS and subsequently functionalized with electrophilic reagents. This...
Catalytic Suzuki couplings by an amido pincer complex of palladium The catalytic feasibility of [PNP]PdCl, where [PNP](-) = bis(2-diphenylphosphinophenyl)amide, on biaryl syntheses from Suzuki-type cross-coupling reactions... LH Liang - 《Journal of Organometallic Chemistry》 被引量: 0发表: ...
Pd-PEPPSI-IPent: low-temperature negishi cross-coupling for the preparation of highly functionalized, tetra-ortho-substituted biaryls. Cool couplings: Complex, hindered biaryls have been prepared at temperatures ranging from 0掳C to room temperature, or with gentle heating. The Pd-PEPPSI-I... S ...
Iron??Catalyzed Aryl–Aryl Cross??Couplings with Magnesium??Derived Copper Reagents [Sapountzis, Ioannis; Lin, Wenwei; Kofink, Christiane C.; Despotopoulou, Christina; Knochel, Paul Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1654 - 1657] ...