三、http://www.organic-chemistry.org/namedreactions/negishi-coupling.shtm 四、Strategic Applications of Named Reactions in Organic Synthesis, László Kürti and Barbara Czakó, Negishi cross-coupling, page 310-311. 根岸英一(Ei-ichi Negishi),日本人,1935年7月出生于中国...
三、http://www.organic-chemistry.org/namedreactions/negishi-coupling.shtm 四、 Strategic Applications of Named Reactions in Organic Synthesis, László Kürti and Barbara Czakó, Negishi cross-coupling, page 310-311. 根岸英一(Ei-ichi Negishi),日本人,1935年7月出生于中国长春,1958年从东京大学毕业后...
在有机化学的广泛领域中,Negishi交叉偶联反应(Negishi Cross-Coupling Reaction)作为一种重要的合成手段,在构建复杂有机分子方面发挥着举足轻重的作用。这一反应因其独特的反应机理以及广泛的应用前景,吸引了众多化学家的研究与探索。本文将深入解析Negishi交叉偶联反应的机理,并探讨其在现代化学合成领域中的广泛应用。 Neg...
Yetong Zhang, Qihang Cao, Yang Xi, Xianqing Wu, Jingping Qu, and Yifeng Chen*.Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas.J. Am. Chem. Soc.2024,...
一、Name Reactions (A Collection of Detailed Reaction Mechanisms), Jie Jack Li, Negishi cross-coupling reaction,page 430-431. 二、化学空间:/reactions/2014/01/%e6%a0%b9%e5%b2%b8%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94%ef%bc%88negishi-coupling%ef%bc%89.html 三、/namedreactions/negishi...
Yetong Zhang, Qihang Cao, Yang Xi, Xianqing Wu, Jingping Qu, and Yifeng Chen*. Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas. J. Am. Chem. Soc.2024, https://doi.org/10.1021/jacs.4c02023 ...
Yetong Zhang, Qihang Cao, Yang Xi, Xianqing Wu, Jingping Qu, and Yifeng Chen*. Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas. J. Am. Chem. Soc.2024, https://doi.org/10.1021/jacs.4c02023...
A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC_(50) = 1-100 n) towards Jurkat, K562, Colo357, and A549 ...
根岸偶联反应(Negishi coupling)是一个有机反应。反应中,有机锌试剂(英语:organozinc compound)与卤代烃在镍或钯的配合物的催化下发生偶联,生成一根新的碳-碳键[1][2]: 其中, 卤素X可以是氯、溴或碘,也可以是其它的基团,如三氟甲磺酰基(英语:triflate)或乙酰氧基,而基团R则可以是烯基、芳基、烯丙基、炔...
Yetong Zhang, Qihang Cao, Yang Xi, Xianqing Wu, Jingping Qu, and Yifeng Chen*. Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas.J. Am. Chem. Soc.2024,https://doi.org/10.1021/jacs.4c02023...