根岸偶联反应(Negishi coupling)是一个有机反应。反应中,有机锌试剂(英语:organozinc compound)与卤代烃在镍或钯的配合物的催化下发生偶联,生成一根新的碳-碳键[1][2]: 其中, 卤素X可以是氯、溴或碘,也可以是其它的基团,如三氟甲磺酰基(英语:triflate)或乙酰氧基,而基团R则可以是烯基、芳基、烯丙基、炔...
根岸偶联反应(Negishi coupling)是一个有机反应。反应中,有机锌试剂(英语:organozinc compound)与卤代烃在镍或钯的配合物的催化下发生偶联,生成一根新的碳-碳键[1][2]: 其中, 卤素X可以是氯、溴或碘,也可以是其它的基团,如三氟甲磺酰基(英语:triflate)或乙酰氧基,而基团R则可以是烯基、芳基、烯丙基、炔...
・Knochel, P.; Singer, R. D.Chem. Rev.1993,93, 2117. DOI:10.1021/cr00022a008 ・Negishi, E. et al.Aldrichimica Acta2005,38, 71.[PDF] ・Pd-Catalyzed Cross Coupling in Total Synthesis: Nicolaou, K. C.; Bulger, P. G.; Sarlah, D.Angew. Chem. Int. Ed.2005,44, 4442. doi...
VOL.38,NO.3•2005EnantiopureSulfoxidesandSulfinamidesTHENEGISHICOUPLING:ANUPDATEPalladium-CatalyzedAlkenylationbytheNegishiCoupli..
根岸耦合反应
The Negishi coupling is the nickel- or palladium-catalyzed reaction between aryl or vinyl halides (or triflates) with organozinc halides. The reaction was first reported by Ei-ichi Negishi in 1977. Several reviews have been published. Mechanism of the Negishi Coupling ...
and cost concerns lead to the examination of other transition metal catalysts for Negishi cross-couplings; nickel has directed to the most impressive developments. Standard nickel complexes, Ni(acac)2in combination with DPE-Phos[141], found to catalyze cross-coupling under milder conditions and a ...
作者: N Coupling 摘要: Transitioning from organoaluminum species to organozinc compounds Negishi and coworkers reported the use of Pd complexes in organozinc coupling reactions and carried out methods studies, eventually developing the reaction conditions into those commonly utilized today. 年份: 1977...
Alkenylation, PalladiumcatalyzedSulfoxides, Enantiopure
EI Negishi - 《Angewandte Chemie》 被引量: 648发表: 2011年 Recent advances in the application of the Sonogashira method in the synthesis of heterocyclic compounds We have presented numerous very useful processes for the synthesis of heterocycles, which involve palladium-catalyzed coupling followed by...