近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文...
研究成果发表在Cancer Letters期刊题为“Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling”。 首先,研究人员全面分析了成纤维细胞的异质性,通过对8个不同样本(6个CRC样本,2个正常结肠样本)进行 scRNA-seq(图1 A、B),发现成纤维细胞聚集成了11个不同的簇(图1 C)。有趣...
Molecular CancerOshima T., Sato S., Kato J., et al. Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Molecular Cancer . 2013; 12 (1, article 60) doi: 10.1186/1476-4598-12-60. [ Cross Ref ]
Alternate Names CD112 antigen; CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; HVEB; HVEBpoliovirus receptor-like 2; MPH; nectin 2; Nectin2; Nectin-2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related prote...
UALCAN database was used to score the gene effects of VDR in colorectal cancer cell lines. The cBioPortal database was used for the detection of gene mutations. The survival curve analysis was carried out using the GEPIA database. The relationship between VDR expression and immune cell ...
用喂养西方饮食或正常饮食的APOE-/-大鼠制作颈动脉粥样硬化(CA)早期病理改变模型。采用有序回归分析评价患者血脂指标与斑块严重程度之间的关系。孟德尔随机化(MR)分析用于确定低密度脂蛋白胆固醇(LDL-C)和动脉粥样硬化之间的因果联系。通过对颈动脉斑块的单细胞转录组和基因芯片数据的匹配分析,确定NECTIN2是影响CA的关键...
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08561(NECTIN2 Antibody) at dilution 1/40. (Original magnification: ×200) 公司简介 湖北艾普蒂生物工程有限公司(简称:艾普蒂)由在国内科研试剂领域有着十几年从业经验的专业技术团队和企业管理团队组建而成,专门从事以...
Nectins are immunoglobulin-like cell adhesion molecules constituting a family with four members, nectin-1, nectin-2, nectin-3, and nectin-4. In the brain, nectin-2 as well as nectin-1 and nectin-3 are expressed whereas nectin-4 is hardly expressed. In the nervous system, physiological func...
The advent of single-cell analysis has provided insights into the landscape and dynamics of immune cell populations within cancer tissues [16, 17]. A previous study using microwell-based single-cell RNA sequencing revealed four distinct subpopulations of TANs in PDAC. Moreover, it identified BHLHE4...
[3] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263. [4] Heath EI, Rosenberg JE. The biology and rationale of targeting nectin-4 in ur...