近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文...
这种新发现的 CAF 可能代表了未来 CRC 免疫疗法的潜在靶点。研究成果发表在Cancer Letters期刊题为“Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling”。 首先,研究人员全面分析了成纤维细胞的异质性,通过对8个不同样本(6个CRC样本,2个正常结肠样本)进行 scRNA-seq(图1 A、...
Nectin-2 was over-expressed in various cancer cell lines as well. Furthermore, the polyclonal antibody specific to Nectin-2 suppressed the in vitro proliferation of OV-90 ovarian cancer cells, which express endogenous Nectin-2 on the cell surface. The anti-Nectin-2 mAbs we generated were ...
Although we found that Nectin-2 was over-expressed in various types of cancers, there has been no report suggesting the involvement of Nectin-2 in cancer cell proliferation. In order to investigate the potential of Nectin-2 as a target for antibody therapies of cancers, we generated anti-Necti...
近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文章,通过单细胞RNA测序技术,深入探索了神经母细胞瘤的免疫微环境。作者通...
近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文章,通过单细胞RNA测序技术,深入探索了神经母细胞瘤的免疫微环境。
UALCAN database was used to score the gene effects of VDR in colorectal cancer cell lines. The cBioPortal database was used for the detection of gene mutations. The survival curve analysis was carried out using the GEPIA database. The relationship between VDR expression and immune cell ...
近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文章,通过单细胞RNA测序技术,深入探索了神经母细胞瘤的免疫微环境。
Interestingly, tumorigenicity is more efficiently suppressed in colon cancer cells overexpressing both Necl-1 and -4 than the cells expressing either of them alone in vitro (Raveh, Gavert, Spiegel, & Ben-Ze’ev, 2009). This suppression of tumorigenicity is associated with enhanced rates of ...
Although the TIGIT nectin-like protein-5 (necl-5) interaction is well understood, how TIGIT engages nectin-2, a receptor that is broadly over-expressed in breast and ovarian cancer, remains unknown. Here, we show that TIGIT bound to the immunoglobulin domain of nectin-2 that is most distal...