PROSTATE cancerNECTINSMEMBRANE proteinsBIOPSYPROSTATECTOMYHEALTH outcome assessmentOBJECTIVE: Nectin-4 is a transmembrane protein belonging to the nectin family of immunoglobulin-like molecules which is found in the placenta and trachea under physiological conditions and its expression has been shown in many...
We believe that prospective studies with more patients and samples including radical prostatectomy materials will reveal the relationship between nectin-4 and prostate cancer more clearly. 展开 关键词: PROSTATE cancer NECTINS MEMBRANE proteins BIOPSY PROSTATECTOMY HEALTH outcome assessment ...
[2]Expression of nectin-4 in prostate cancer. North Clin Istanb. 2023 Sep 25;10(5):583-588. doi: 10.14744/nci.2023.36034. PMID: 37829757; PMCID: PMC10565758. [3]Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment. Cancers (Basel). 20...
乳腺癌细胞系：如MCF-7和BT-474细胞系，这些细胞系内源性表达Nectin-4。此外，MDA-MB213细胞系（MDA...
Nectin-4 and p63 immunohistochemical expression in canine prostate tumourigenesis Nectinis an Eヽadherin‐based adherens junction protein of normal epithelial cells, as well as a potent mediator of anchorage﹊ndependent cancer colony for... L Della Salda,M Massimini,M Romanucci,... - 《Veterinary...
Nectin-4, upregulated in various cancer cells, cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, p95-ErbB2 and ErbB2∆Ex16, enhancing DNA synthesis through the PI3K-AKT signaling in human breast cancer T47D cells in an adherent cu
Recently, Nectin-4 overexpression has been documented in breast, lung and ovarian carcinomas,13–17 but the biological significance of this finding in human cancer progression as well as its potential role as a diagnostic and therapeutic biomarker in early breast cancer have not been established. ...
GU tumors were included, 14 on UBC, three on upper tract urothelial carcinoma (UTUC), six on histologic subtypes (HS) and divergent histology of the bladder, one on papillary renal cell carcinoma (pRCC), one in chromophobe RCC (chRCC), two on penile cancer, one in prostate cancer (PCa)...
(ADC) composed of a humanized IgG1 antibody targeting six-transmembrane epithelial antigen of the prostate 1 (STEAP1), a cell surface protein that is upregulated in prostate cancer and certain other cancers, yet has limited expression in normal healthy tissue. Adcentrx's proprietary i-...
The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and me