In vitro, TN can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. TN is best known as a prognostic marker in ovarian cancer. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
TIGIT: a key inhibitor of the cancer immunity cycle Trends Immunol. (2017) R.J. Johnston et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8 + T cell effector function Canc. Cell (2014) F.A. Deuss et al. Recognition of nectin-2 by the natural killer cell receptor T ...
Human CD113 / Nectin-3 AntibodyRat CD112 / Nectin-2 / PVRL2 Antibody Receptor Antibody-Flow Cytometry / FACS Human EGFR / HER1 / ErbB1 AntibodyHuman Transferrin Receptor / TFRC / CD71 Antibody Human HER2 / ErbB2 AntibodyHuman OSMR / IL-31RB Antibody ...
Positive Control: Rat skin tissue lysate, human skin tissue lysate, HepG2, MCF-7, human liver cancer tissue, human kidney tissue. 靶标信息 Tetranectin (TN) is a serum and tissue protein, a C-type lectin, which binds to Ca++. It is a homotrimer of monomers each with a mass of...
Immunocytokines: A promising approach to cancer immunotherapy. Pharmacology Therapeutics 80:277-292, 1998 (Exhibit 13). Erikson HP. et al. Hexabrachion protein (tenascin, cytotactin, brachionectin) in connective tissues, embryonic tissues and tumors. Adv Cell Biol 2:55-90, 1988 (Exhibit 14)...
In one embodiment, the present invention provides conjugates of an anti-Nectin-4 antibody to a camptothecin analogue, such as exatecan or SN-38, through... M Kraiem 被引量: 0发表: 2021年 TREATMENT OF CANCER In one embodiment, the present invention provides conjugates of an anti-Nectin-4 an...
1996, Journal of Neuropathology and Experimental Neurology Expression and Effects of Hyaluronan and of the Hyaluronan‐Binding Protein Hyaluronectin in Newborn Rat Brain Glial Cell Cultures 1994, Journal of Neurochemistry View all citing articles on ScopusView...
The Nectin-4 expression on tumor tissue was not a requirement for eligibility. There was no dose-limiting toxicity observed, the dose escalation beyond 3.6mg/kg is continuing to be explored. The maximum tolerated dose has not yet been reached. In 16 subjects who have received at least one ...
HER2 / ErbB2 / CD340 AntibodyGM-CSF / CSF2 Antibody CD112 / Nectin-2 / PVRL2 AntibodyIL12A / IL-12A Antibody VEGF121 / VEGF-A Antibody4E-BP1 / EIF4EBP1 Antibody bFGF / FGF2 AntibodyCD27 / TNFRSF7 Antibody NRP1 / CD304 Antibody2B4 / CD244 Antibody ...
(TNF-a Conectin, DIF, TNFSF2), TNFSF1B (TNF-b LTa, TNFSF1), TNFSF3 (LTb TNFC, p33), TNFSF4 (OX40 Ligand gp34, TXGP1), TNFSF5 (CD40 Ligand CD154, gp39, HIGM1, IMD3, TRAP), TNFSF6 (Fas Ligand Apo-1 Ligand, APT1 Ligand), TNFSF7 (CD27 Ligand CD70), TNFSF8 (CD...