Poliovirus receptor-related 2 (PVRL2) and Poliovirus receptor (PVR) are members of the Nectin and Nectin-like Molecules family, known for their role as cell-cell adhesion molecules. With the development of immunotherapy, their involvement in tumor immune mechanisms as immune c...
Poliovirus receptor-related 2 (PVRL2) and Poliovirus receptor (PVR) are members of the Nectin and Nectin-like Molecules family, known for their role as cell-cell adhesion molecules. With the development of immunotherapy, their involvement in tumor immune mechanisms as immune checkpoint factors has ...
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evading, and exploiting the host immune system. Immunotherapy is a form of oncologic treatment directed towards enhancing the host immune system against cancer. In recent years, manipulation of immune checkpoints or pathways has emerged as an important and effective form of immunotherapy. ...
For patients with cancer, treatment may include combination therapy, including surgery and immunotherapy. Here, we review perioperative considerations for the patient prescribed immunotherapeutic agents. Recent Findings The perioperative period is a poignant moment in the journey of a patient with cancer, ...
Anticancer immunotherapy through checkpoint blockade enables the patient to mount active antitumour responses and can dramatically improve survival. In this Review, Mahoney, Rennert and Freeman examine targets for next-generation immunomodulators and dis
The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Kohrt et al. Journal for ImmunoTherapy of Cancer (2016) 4:15 Page 2 of 16 Table 1 Immunoprognostic and ...
Nectin cell adhesion molecule 4 (NECTIN4), a member of the NECTIN family, a group of Ca2+-independent immunoglobulin-like molecules, is significantly overexpressed in PTC and modulates EMT by activating the PI3K/AKT signalling pathway to drive PTC metastasis [89, 90]. EMT-inducing transcription ...
AKT Isoforms as a Target in Cancer and Immunotherapy © 2022 Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression Introduction The discovery ofAktas an oncogene dates to about four decades ago, when a novel transforming retrovirus, isolated from an AKR mouse T cell ly...
and eventually become spindle-shaped (PD-SCCs and PD/S-SCCs; G3-G4 grade). These advanced cSCCs have a high risk of relapse and metastasis4, and are commonly treated with radiotherapy and/or chemotherapy, which bestow limited clinical benefits5. Immunotherapy based on two programmed cell deat...