Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncology, an increasing number of novel immunoregulatory targets and mechanisms are being revealed, ...
摘要: Provided are an anti-Nectin-4 antibody or an antigen-binding fragment thereof, an antibody conjugate including same, and a use thereof in the preparation of a medicament, particularly in the preparation of a medicament for preventing and/or treating cancer....
Glby, Encoded by MAB_3167c, Is Required for In Vivo Growth of Mycobacteroides abscessus and Exhibits Mild β-Lactamase Activity. PMID: 35380462 Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer. PMID: 35614462 Antibody-based in vivo leukocyte label...
12,13. We showed that supplementation of T cell cultures with esterified forms of S-2HG enhances T cell immunotherapy in preclinical models, where it acts by promoting the development of central memory T (TCM) cells. 2HG and
(ADC) that targets the expression of Nectin-4 on cancer cells to release a cytotoxic payload and CRB-601, an anti-integrin monoclonal antibody which blocks the activation of TGFβ expressed on cancer cells. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus,...
hTERT-siTCR vector was transfected into normal CD8+ T cells in RetroNectin (Takara Bio Inc.) coated-plates and these redirected CD8+ T cells (hTERT-siTCR CD8) were used as effector cells. HLA-A*24:02+ or A*24:02 ATL cell lines, HTLV-1 infected T-cell lines...
Nectin-like Protein 2 Defines a Subset of T-cell Zone Dendritic Cells and Is a Ligand for Class-I-restricted T-cell-associated Molecule. J Biol Chem. 2005;280:21955–64. CAS PubMed Google Scholar Yeh J-H, Sidhu SS, Chan AC. Regulation of a Late Phase of T Cell Polarity and ...
Although chimeric antigen receptor (CAR) T cells are effective against B-lineage malignancies, post-CAR relapse is common, and efficacy in other tumors is limited. These challenges may be addressed through rational manipulations to control CAR T cell fun
Alternate Names 170 kDa melanoma membrane-bound gelatinase; DKFZp686G13158; DPPIV; EC 3.4.21.-; FAP; FAPA; Fibroblast Activation Protein alpha; fibroblast activation protein, alpha; Integral membrane serine protease; Seprase; vibronectin
Briefly, splenocytes from Vk12653 bearing Rag2−/−Il2rg−/− mice were harvested and transduced in vitro with huCD38 lentiviral vector at a multiplicity of infection of 10 on retronectin-coated plates for 1 hour. As VK*MYC cells do not survive in culture, transduced cells were ...