We show that tissue damage caused by dextran sulfate sodium feeding stimulates dMyc expression via the Hpo pathway, whereas bleomycin feeding activates dMyc through the JAK-STAT and EGFR pathways. We provide evidence that dMyc expression is transcriptionally upregulated by multiple signaling pathways,...
tri-specific targeted therapy to VEGFR/FGFR/RET, suppresses angiogenesis through the inhibition of both VEGFR and FGFR signaling pathways. In Cancer Research (Vol. 75, Issue 15_Supplement, pp. 1374–1374).
Therefore, it is not surprising that the MYC signaling pathway is considered a potential therapeutic target for cancer therapy due to its role in tumors. Furthermore, increasing evidence suggests that MYC hyperactivation can mediate tumor-induced immunosuppression at multiple levels [8, 9]. ...
TTI-101 targets STAT3/c-Myc signaling pathway to suppress cervical cancer progression: an integrated experimental and computational analysis 来自 科研支点 喜欢 0 阅读量: 5 作者:Y Li,Y Dong 摘要: Cervical cancer (CC) is a significant global health concern, demanding the consideration of novel ...
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer 图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质代谢有影响。PI3K-Akt-信号传导可以通过 S6K1 的信号传导促进SREBP1 活性形式的积累[31, 86]。Akt 介导的 FoxO 抑制减轻会对SREBP-1c的抑制;此外,Akt 对 GSK-3β 的抑制也增强...
Human gastric cancer AGS and HGC-27 cells were treated with PKM2 and c-Myc lentivirus, and the effects of the knockdown of PKM2 and/or c-Myc were analyzed on cell proliferation, cell apoptosis, the ability of cell migration, and the growth signaling pathway in vitro. The expressions of ...
the researchers firstly performed RNA-seq on T-ALL cells treated with PBS or HHT. Results showed that both the MYC target V1 and NOTCH signaling pathways were among the top six gene sets altered by HHT treatment, with...
(NHEJ) pathway is a major pathway for DSB repair and is highly aberrant in TK-activatedleukemias; an alternative form of NHEJ (ALT-NHEJ) predominates, evidenced by increased expression of DNA ligase IIIα (LIG3) and...
study aimed to investigate the effect of calponin 1 (CNN1) on the invasion and migration of lung squamous cell carcinoma (LUSC) cells and the associations between CNN1, tissue inhibitor of metalloproteinases 2 (TIMP2), Dickkopf-1 (DKK1) and the Wnt/β-catenin/c-myc signaling pathway. The...
http://.paper.edu -1- 中国科技论文在线 c-Myc与核呼吸因子-1在细胞凋亡中的作用 # 桑灏,张丽娟,李觉 ** 基金项目:教育部博士点基金(No.20100072120053);国家自然科学基金青年基金(No.81001252)) 作者简介:桑灏(1988-),女,硕士研究生,主要研究方向:流行病与卫生统计 通信联系人:**娟(1977-),女,讲师,...