Our study highlighted the function of targeting the HDAC7/c-Myc signaling pathway to intervene in the pathological process of CM, which provides potential therapeutic strategies for CM treatment.doi:10.1038/s41419-022-05522-0Yimeng Zhanggrid.233520.50000 0004 1761 4404Department of Ophthalmology, ...
此外,MYH9的耗竭显著抑制了体内肿瘤生长(P<0.001)。分子机制表明,敲除MYH9使AKT/c-Myc轴失活(P<0.05),从而抑制BCL-2样蛋白1的表达(P<0.05),促进BH3相互作用结构域死亡激动蛋白和凋亡调节剂BAX的表达(P<0.05),并激活胱天蛋白酶3和胱天蛋白酶9(P<0.05)。结论 MYH9通过AKT/c-Myc轴调节细胞凋亡,从而促进NSCLC...
TTI-101 targets STAT3/c-Myc signaling pathway to suppress cervical cancer progression: an integrated experimental and computational analysis 来自 科研支点 喜欢 0 阅读量: 5 作者:Y Li,Y Dong 摘要: Cervical cancer (CC) is a significant global health concern, demanding the consideration of novel ...
Furthermore, we determined that the anti-osteosarcoma activity of diosmetin was possibly attributed to suppressed activation of STAT3/c-Myc signaling pathway as it dose-dependently inhibited STAT3 phosphorylation and reduced c-Myc expression as well as inhibited STAT3 dimerization while its anti-...
The c-Myc oncoprotein plays a prominent role in cancer initiation, progression, and maintenance. Long noncoding RNAs (lncRNAs) are recently emerging as critical regulators of the c-Myc signaling pathway. Here, we report the lncRNA USP2-AS1 as a direct transcriptional target of c-Myc. Functiona...
Human gastric cancer AGS and HGC-27 cells were treated with PKM2 and c-Myc lentivirus, and the effects of the knockdown of PKM2 and/or c-Myc were analyzed on cell proliferation, cell apoptosis, the ability of cell migration, and the growth signaling pathway in vitro. The expressions of ...
c-MYC inhibition results in decreased LIG3 and PARP1 levels in FLT3/ITD- and BCR-ABL1- positive cells. Figure 2. c-MYC induces the transcription of LIG3 and PARP1 in FLT3/ITD- and BCR-ABL1- positive cells (...
PI3K-Akt 信号还可以直接磷酸化抑制的糖原合酶激酶 3β (GSK-3β)来防止 Thr58 处的 c-Myc 磷酸化及其随后的降解[85]。 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer 图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质代谢有影响。PI3K-Akt-信号传导可以通过 S6K1 的信号...
Here we demonstrated, for the first time, that the central oncogenic c-MYC signaling pathway, previously shown to have important roles in PCa progression13, is directly activated by IRE1α signaling through XBP1s. Consistently, depleting XBP1s either by the IRE1α RNase-specific inhibitor MKC8866...
Wnt/β-catenin signaling pathway dysregulation could induce proliferation, survival, metastasis, EMT process and recurrence of tumors [36]. C-Myc is a proto-oncogene, which locates on human chromosome 8q24 and belongs to Myc family [37]. C-Myc regulates expression of many genes by regulating ...