PI3K-Akt 信号还可以直接磷酸化抑制的糖原合酶激酶 3β (GSK-3β)来防止 Thr58 处的 c-Myc 磷酸化及其随后的降解[85]。 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer 图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质代谢有影响。PI3K-Akt-信号传导可以通过 S6K1 的信号...
In the xenograft model, TTI-101 significantly inhibited tumor growth without adverse effects on body weight.TTI-101 exhibited anticancer effects by targeting the STAT3/c-Myc signaling pathway, inducing cell cycle arrest, and promoting apoptosis in CC cells. These findings provide valuable insights ...
此外,MYH9 的耗竭显著抑制了体内肿瘤生长(P<0.001).分 子机制表明,敲除 MYH9 使 AKT/c-Myc 轴失活(P<0.05),从而抑制 BCL-2 样蛋白 1 的表达(P<0.05),促进 BH3 相互作用结构域 死亡激动蛋白和凋亡调节剂BAX的表达(P<0.05),并激活胱天蛋白酶3和胱天蛋白酶9(P<0.05).结论 MYH9通过AKT/c-Myc 轴调节...
the student’s t-test. (D and E) siRNA-mediated knockdown of c-MYC and si-MYC controls in TK-activated cell lines and examination LIG3 and PARP1 expression levels in (D) extracted mRNA by PCR in (left panel)...
Besides, c-MYC mRNA was significantly upregulated in macrophages after CSF-1 stimulation, boosting macrophage proliferation [63].Via JAK1/STAT3 signaling pathway, IL-11 induces c-MYC expression to promote breast cancer bone metastasis [83]. The chemokine CCL20 activates AKT pathways to enhance ...
TGF-MAPK/ERK-c-myc通路介导慢性萎缩性胃炎(CAG)胃黏膜细胞的增殖与凋亡,在其通路的不同环节出现调控失常,导致胃黏膜细胞过度增殖和凋亡不足,最终导致癌变。本课题在前期临床和实验研究的基础上,以饮用化学致癌剂MNNG复制CAG大鼠模型,运用免疫组化、RT-PCR,Western Blot等现代分子生物学技术检测TGF-MAPK/ERK -c-my...
C-Myc调控细胞转录 已有研究表明,C-Myc编码的核磷蛋白与MAX结合成异二聚体时可以起转录激活剂的作用,但当其与MAX二聚体蛋白(MAX dimerization protein,MXD)家族转录因子结合时又转变为抑制转录作用[7]。C-Myc调控转录有2种模式:染色质侵犯和选择性调节。...
Tensin 4 facilitates aerobic glycolysis, migration and invasion of colorectal cancer cells through the βcatenin/cMyc signaling pathway doi:10.3892/ol.2024.14489COLORECTAL cancerGLYCOLYSISCELLULAR signal transductionCANCER cellsGENETIC transcriptionTensin 4 (TNS4) is overexpressed in multiple...
图2.2 C-Myc/MAX异二聚体结合DNA的x射线结构示意图 C-MYC在多种组织和肿瘤中广泛表达,是Wnt信号通路中β-catenin-TCF/LEF复合物的下游靶基因,定位于人染色体8p24,编码一个62kD核内磷酸化蛋白,是大量生长促进信号传导通路的交叉汇合点,协调增殖、凋亡、分化和新陈代谢。同时也是许多配体-膜受体复合物下游的早期...
We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner. Specifically, agents that initiate t... Kathleen,Kelly,and,... - 《Cell》 被引量: 3307发表: 1983年 Direct inhibition of the signaling functions of the mammalian target ...