Targeted inhibition of c-Myc inhibited CM progression by interfering with the HDAC7/c-Myc signaling pathway. Our study highlighted the function of targeting the HDAC7/c-Myc signaling pathway to intervene in the pathological process of CM, which provides potential therapeutic strategies for CM ...
TTI-101 targets STAT3/c-Myc signaling pathway to suppress cervical cancer progression: an integrated experimental and computational analysis 来自 科研支点 喜欢 0 阅读量: 5 作者:Y Li,Y Dong 摘要: Cervical cancer (CC) is a significant global health concern, demanding the consideration of novel ...
DNA double-strand breaks (DSBs) and error-prone repair. The non-homologous endjoining (NHEJ) pathway is a major pathway for DSB repair and is highly aberrant in TK-activatedleukemias
Abstract The c-Myc oncoprotein plays a prominent role in cancer initiation, progression, and maintenance. Long noncoding RNAs (lncRNAs) are recently emerging as critical regulators of the c-Myc signaling pathway. Here, we report the lncRNA USP2-AS1 as a direct transcriptional target of c-Myc....
c-Myc GAPDH D 1.5 1.0 H1299 *** LV-sgNC LV-sgMYH9 * 0.5 0 AKT p-AKT (ser473) c-Myc 1.5 H1975 LV-sgNC LV-sgMYH9 *** *** 1.0 0.5 0 AKT p-AKT (ser473) c-Myc 图5 MYH9通过ATK/c-Myc信号通路调节凋亡 Fig.5 MYH9 regulates apoptosis through the AKT/c-Myc signaling pathway...
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer 图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质代谢有影响。PI3K-Akt-信号传导可以通过 S6K1 的信号传导促进SREBP1 活性形式的积累[31, 86]。Akt 介导的 FoxO 抑制减轻会对SREBP-1c的抑制;此外,Akt 对 GSK-3β 的抑制也增强...
Human gastric cancer AGS and HGC-27 cells were treated with PKM2 and c-Myc lentivirus, and the effects of the knockdown of PKM2 and/or c-Myc were analyzed on cell proliferation, cell apoptosis, the ability of cell migration, and the growth signaling pathway in vitro. The expressions of ...
Furthermore, we determined that the anti-osteosarcoma activity of diosmetin was possibly attributed to suppressed activation of STAT3/c-Myc signaling pathway as it dose-dependently inhibited STAT3 phosphorylation and reduced c-Myc expression as well as inhibited STAT3 dimerization while its anti-...
p63-Mediated activation of the 尾-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinoma cell invasion and metastasis Lee KB;Ye S;Park MH;.p63-Mediated activation of the β-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinomacell invasion and metastasis... KB Lee...
Our previous study demonstrated that p63 is highly expressed in human ESC cells, and that p63 stimulates the growth of ESC cells by activation of the Akt signaling pathway [21]. However, the mechanism by which p63 regulates ESC cell adhesion and invasion is unknown. Therefore, in the present...