我们的发现不仅提高了我们对维持CSCs干性和致瘤性的分子机制的理解,而且也表明CDK8-c-myc轴可能成为未来开发多种癌症新疗法的靶点,这些癌症的恶性程度与CSCs的实体有关。 reference:CDK8 maintains stemness and tumorigenicity of glioma stem cell...
现已被证明通过小分子抑制C-Myc和Max之间的相互作用,可有效抑制C-Myc相关功能。最近有肿瘤模型的临床前研究报道称,一些直接或间接靶向C-Myc的化合物具有抗癌活性,现如今,在多种癌症治疗中,C-Myc成为更有潜力的药物靶点。 图1.1 MYC调节癌症的所有特征 02 C-Myc结构与功能 C-Myc是一种含有439个氨基酸的癌蛋白,...
为明确CU27的主要作用靶点,研究人员首先对CU27处理后的细胞进行转录组学分析、Ingenuity Pathway Analysis(IPA)分析、基因集富集分析(GSEA),分析结果均提示c-Myc是CU27的主要生物靶标分子。随后我们检测了c-Myc的部分关键靶基因的表达...
Yagi, K, Furuhashi, M, Aoki, H, Goto, D, Kuwano, H, Sugamura, K, Miyazono, K, Kato, M (2002) c-myc is a downstream target of the Smad pathway. J Biol Chem 277: pp. 854-861Yagi K, Furuhashi M, Aoki H, et al. c-myc is a downstream target of the Smad pathway. J Biol...
www.nature.com/scientificreports OPEN Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cells received: 10 December 2015 accepted: 25 May 2016 Published: 06 July 2016 Shiwani Tiwari1, Chris Roel1, Mansoor Tanwir2, Rachel Wills2, Nidhi Perianayagam1, Peng Wang1 & ...
关键词:MYH9;CRISPR-Cas9;非小细胞肺癌;细胞凋亡;顺铂耐药;Akt/c-Myc 信号通路 High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway LIU Fang1, PENG Lanzhu2, XI Jingle1 1Department of Oncology, Nanfang Hospital, Southern Medical ...
c-Myc Inhibitors on signaling pathway are available at Adooq Bioscience. Check c-Myc pathway , inhibitors reviews and assay information.
[2] Horiuchi D, Kusdra L, Huskey NE, et al. Myc pathway activation in triple-negative breast cancer is synthetic lethal with cdk inhibition. The Journal of experimental medicine, 2012, 209: 679-696 [3] Casey SC, Baylot V, Felsher DW. The myc oncogene is a global regulator of the imm...
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer 图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质代谢有影响。PI3K-Akt-信号传导可以通过 S6K1 的信号传导促进SREBP1 活性形式的积累[31, 86]。Akt 介导的 FoxO 抑制减轻会对SREBP-1c的抑制;此外,Akt 对 GSK-3β 的抑制也增强...
分别对正、负离子模式下的数据进行主成分分析(principal component analysis,PCA)和正交偏最小二乘-判别分析(orthogonal partial least squares-discriminant analysis,OPLS-DA)等多元统计分析,采用京都基因和基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)、代谢途径分析(metabolic pathway analysis,MetPA)...