我们的发现不仅提高了我们对维持CSCs干性和致瘤性的分子机制的理解,而且也表明CDK8-c-myc轴可能成为未来开发多种癌症新疗法的靶点,这些癌症的恶性程度与CSCs的实体有关。 reference:CDK8 maintains stemness and tumorigenicity of glioma stem cell...
Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABLPhiladelphia-positive chronic myeloid leukemiaPhiladelphia-positive acute lymphoblastic leukemiaSTAT6c-MycJak2The Philadelphia chromosome encodes the BCR-ABL fusion protein, which...
The Lin28/let-7a/c-Myc pathway plays a role in non-muscle invasive bladder cancer. Cell Tissue Res. 2013;354(2):533-41.Y. Li, H. Liu, C. Lai, X. Du, Z. Su, and S. Gao, "The Lin28/let-7a/c-Myc pathway plays a role in non-muscle invasive bladder cancer," Cell Tissue...
Wills, RachelPerianayagam, NidhiWang, PengFiaschi-Taesch, Nathalie M.Nature Publishing GroupScientific ReportsTiwari, S.; Roel, C.; Tanwir, M.; Wills, R.; Perianayagam, N.; Wang, P.; Fiaschi-Taesch, N.M. Definition of a Skp2-c-Myc Pathway to Expand Human B-cells. Sci. Rep. ...
c-Myc Inhibitors on signaling pathway are available at Adooq Bioscience. Check c-Myc pathway , inhibitors reviews and assay information.
c-MYC inhibition results in decreased LIG3 and PARP1 levels in FLT3/ITD- and BCR-ABL1- positive cells. Figure 2. c-MYC induces the transcription of LIG3 and PARP1 in FLT3/ITD- and BCR-ABL1- positive cells (...
Akt 的激活会减轻FoxO 介导的对c-Myc 的抑制[84]。PI3K-Akt 信号还可以直接磷酸化抑制的糖原合酶激酶 3β (GSK-3β)来防止 Thr58 处的 c-Myc 磷酸化及其随后的降解[85]。 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer 图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质...
We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo, and importantly, aberrant expression of PSPH is highly correlated with mortality in hepatocellular carcinoma (HCC...
In this study, we identify the c-Myc/miR-29c/REV3L sig- nalling pathway as a master regulator of TMZ resistance, and suggest that disruption of the c-Myc/miR-29c/REV3L signalling pathway may have dual anticancer effects, sensi- tizing resistant tumours to TMZ as well as preventing the...