As our results showed that CEP120 is required to recruit C2CD3 and Talpid3 to the distal ends of centrioles (Fig.3a,b), we next examined whether CEP120 could interact with C2CD3. Indeed, our co-immunoprecipitation (co-IP) results showed that full-length CEP120-myc could form a complex...
2020-Molecular Cancer-IF(27.4)CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc pdf下载 >> · 2021-GUT-IF(23.05)Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast... pdf下载 >> ...
In this study, we investigated the pathway of caspase-2 activation during apoptosis induced by NO in E1A-expressing cells. Our data show that caspase-2 is the initiator caspase in response to NO injury and is required for NO-induced mitochondrial injury. NO induces processing of PIDD from PI...
PHM induced apoptosis via downregulation of anti-apoptotic (survivin, B-cell lymphoma Extra-large; BCL-XL, X-linked inhibitor of apoptosis protein; XIAP, Myelocytomatosis; C-myc), metastatic (Matrix metallopeptidases 9/2; MMP9/2), and cell-cycle regulatory (cyclin D1 and E) proteins, ...
2022-Scientific Reports-IF(4.38)DJ‑1 upregulates the Nrf2、GPX4 signal pathway to inhibit trophoblast ferroptosis in t... pdf下载 >> · 2022-Journal of Cancer Research and Clinical Oncology-IF(4.32)Targeting NAD metabolism regulates extracellular adenos... ...
机制示意图。RNF122催化JAK2的K63的非降解性泛素化修饰,并进一步促进JAK2的磷酸化激活。磷酸化的JAK2然后激活其下游蛋白stat3。磷酸化的STAT3进入细胞核,促进c-myc的转录激活和蛋白表达水平。作为一种常见的致癌蛋白,c-myc可进一步促进胶质母细胞瘤的恶性进展。
Based on both in vivo and in vitro experiments, numerous evidences indicated that Brusatol was able to inhibit c-Myc/ROS pathway, then increase HIF-1α through promotion of 20 DOI: 10.55415/deep-2022-0032.v1 prolyl hydroxylases (PHDs) activity, and finally induce cancer cell death in ...
HJURP inhibited YAP1 ubiquitination and regulated the yes-associated protein 1 (YAP1)/ N-myc downstream regulated 1 (NDRG1) pathway to promote cell proliferation and decrease response to chemotherapy. Therefore, HJURP may be a candidate prognosis biomarker for breast cancer and a therapeutic target...
品名: IL2 Pathway PCR Array plate 种属: HUMAN 货号: WC-MRNA0180-H 规格: 96孔板 品牌: Wcgene® biotech 产品: 96孔引物预置板,封板膜,说明书 储存: -20℃ 有效期: 六个月 生产日期: 见外包装 使用限制: 本产品仅供科研使用,不应用于诊断、预防和治疗疾病。基因...
品名: p53 Signaling Pathway PCR Array plate 种属: HUMAN 货号: WC-MRNA0117-R 规格: 96孔板 品牌: Wcgene® biotech 产品: 96孔引物预置板,封板膜,说明书 储存: -20℃ 有效期: 六个月 生产日期: 见外包装 使用限制: 本产品仅供科研使用,不应用于诊断、预防和治疗疾病。