原名:Compound Kushen Injection intervenes metabolic reprogramming and epithelial-mesenchymal transition of HCC via regulating β-catenin/c-Myc signaling 译名:复方苦参注射液通过调节β-catenin/c-Myc信号干预HCC代谢重编程和上皮间...
Activation of c-Myc signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can also mediate drug resistance and radioresistance in cancers. The apoptosis inhibition and enhancing cell cycle progression are mediated by c-Myc overexpression. On the other hand, ...
Keywords: MYH9; CRISPR-Cas9; non-small cell lung cancer; cell apoptosis; cisplatin resistance; Akt/c-Myc signaling 肺癌是全球发病率第2,死亡率排名第1的癌症[1, .2] 非小细胞肺癌(NSCLC)是肺癌中最常见的类型,占全 部肺癌的 80%~85%[3].患者生存率与肿瘤分期相关,晚 收稿日期:2022-12-12 基金...
现已被证明通过小分子抑制C-Myc和Max之间的相互作用,可有效抑制C-Myc相关功能。最近有肿瘤模型的临床前研究报道称,一些直接或间接靶向C-Myc的化合物具有抗癌活性,现如今,在多种癌症治疗中,C-Myc成为更有潜力的药物靶点。 图1.1 MYC调节癌症的所有特征 02 C-Myc结构与功能 C-Myc是一种含有439个氨基酸的癌蛋白,...
RNA sequencing (RNA-seq) analysis of MKC8866-treated orXBP1knockdown PCa cells revealed that IRE1α-XBP1s is essential for c-MYC signaling, a central oncogenic regulatory pathway in PCa12,13. These results establish IRE1α-XBP1s signaling as a potential target for alternative treatment strategies...
NCAPG2 promotes PCa malignancy and drives cancer stemness via the STAT3/c-MYC signaling axis, highlighting its potential as a therapeutic target for PCa.Journal of Translational MedicineZhang, EnchongChen, ZhengjieLiu, WangminLin, LinWu, LinaGuan, JohnnyWang, JianfengKong,...
The opposing roles of the Akt and c-myc signaling pathways in survival from CD95-mediated apoptosis. Oncogene 1998;17:2811-8.Rohn JL, Hueber AO, McCarthy NJ, Lyon D, Navarro P, Burgering BM, Evan GI 1998 The opposing roles of the Akt and c-Myc signalling pathways in survival from ...
Wnt/c-Myc signaling directly enhances MYU expression. MYU forms a complex with hnRNP-K and stabilizes CDK6 expression by suppressing the inhibitory effect of miR-16 and thereby facilitates cell-cycle progression. The MYU/hnRNP-K/CDK6 pathway and the CDK4 pathway may contribute independently to ...
图:PI3K-Akt-mTOR signaling pathway[76] PI3K – Akt还对脂质代谢有影响。PI3K-Akt-信号传导可以通过 S6K1 的信号传导促进SREBP1 活性形式的积累[31, 86]。Akt 介导的 FoxO 抑制减轻会对SREBP-1c的抑制;此外,Akt 对 GSK-3β 的抑制也增强了 SREBP 的稳定性,避免SREBP被 GSK-3β的磷酸化引导 SCFFbw7泛素...
多发性骨髓瘤(multiple myeloma,MM)是一种浆细胞恶性增殖性疾病,其特点为克隆性浆细胞在骨髓中异常增殖,发病率在血液系统肿瘤中排第2位。C-Myc是一种原癌基因,在人类的多种实体肿瘤和血液肿瘤中异常高表达。近年来相关研究表明,C-Myc的表达增强与肿瘤的不...