Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression . Oncogene 25: 304–309Bossi G., Lapi E., Strano S., Rinaldo C., Blandino G., Sacchi A. (2006) Mutant p53 gain of function: reduction of tumor malignancy ...
Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene 2003; 22: 5667–5676. 36 Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M et al. Transactivation of the EGR1 gene contributes to mutant p53 gain ...
TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emerging evidence suggests that mutp53 is high...
gain of function mutant 功能突变体的获得 例句：1.Central nervous system hyperexcitability associated with glutamate dehydrogenasegain of function mutations 中枢神经系统兴奋性过高与谷氨酸脱氢酶获得性功能突变 2.Five IGFBP 3 mutants were generated after DNA sequence analysis, then theinteractions ...
(PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens and this co-occurrence accelerates prostatic oncogenesis. p53 gain-of-function (GOF) mutants are now shown to bind to a unique DNA sequence in the CTNNB1 gen...
Thereafter, it can further manifest mutant p53 gain of function in lymphoma cells, as p53 and AKT inhibition by GNE477, SC66 and PFT-α suppressed tumor growth (Supplementary Figure 3A-3J).Mutant p53 activates AKT through directly binding to PHLPP2 promoter and down-regulates its transcription...
Recently, evidence of gain-of-function (GoF) p53 mutations that exert WT function-independent oncogenic effects in cancer biology is emerging [1]. The GoF p53 mutant is increasingly recognized as an important driver of tumor pathogenesis in various cancer types. The acquisition of key GoF p53 ...
these mutants lose the typical tumor-suppressive features of p53 to variable degrees. The gain-of-function impact of stabilized mutant p53 causes tumor-specific dependency and resistance to therapy. P53 is a prospective target for cancer therapy because of its tumor-suppressive qualities and the nume...
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy Oncogene, 18 (1999), pp. 477-485 CrossrefView in ScopusGoogle Scholar Boeckler et al., 2008 F.M. Boeckler, A.C. Joerger, G. Jaggi, T.J. Rutherford, D.B. Vepr...
Mutant p53 can attenuate the function of wild-type p53, p63 and p73. An aggregation-nucleating sequence in p53 that is revealed in structurally destabilized mutants can induce coaggregation with p63 and p73, resulting in their sequestration in cellular i