p53 K117R mutant knock-in mice, which completely abolished p53-mediated apoptosis [8]. In comparison to p53-deficient or p53 wild-type tumors, tumors carrying mutp53 exhibit more aggressive and metastatic properties [9,10,11]. GermlineTP53mutations are the cause of Li-Fraumeni syndrome, which...
[2]Fudan University Shanghai Cancer CenterHua Lu[3]Department of Biochemistry & Molecular Biology and Tulane Cancer Center分子细胞生物学报(英文版)Zhou, X., Hao, Q. and Lu, H. (2018) Mutant p53 in cancer therapy - the barrier or the path. J. Mol. Cell Biol., [Epub ahead of print]...
Novel anticancer drugs that reactivate mutant p53 should have wide clinical applicabilityAbstract The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type p53 can suppress tumour development by multiple pathways. However, mutation of TP53 and the resultant inactivation of...
Cell Video Abstract Prion-like aggregation of mutant p53 in cancer https://www.youtube.com/watch?v=eN8Twyo8nNA JL Silva,CVDM Gallo,DCF Costa,... 被引量: 4发表: 2015年 The aggregation of mutant p53 produces prion-like properties in cancer The tumor suppressor protein p53 loses its ...
Small molecule induced reactivation of mutant p53 in cancer cells. The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface cre... Xiangrui,Liu,Rainer,... - 《Nucleic Acids Research》 被引量: 116...
Pancreatic ductal adenocarcinoma (PDAC) is one cancer type in which mutant p53 impacts disease progression. PDAC arises from indolent pancreatic intraepithelial neoplasias (PanINs) that frequently go undetected and persist for many years. However, the conversion of PanINs to highly aggressive, frankly...
in the presence of p53 mutations, holds great promise for cancer treatment. In addition, mutant p53 often exhibits novel gain-of-functions to promote tumor growth and metastasis. Here, we review and discuss strategies targeting mutant p53, with focus on targeting the mutant p53 protein directly,...
aMutant p53 accumulation in human breast cancer is not an intrinsic property nor dependent on structural or functional disruption but is regulated by exogenous stress and receptor status. 突变体p53储积在人的乳腺癌不依靠固有特性亦不结构或功能中断,而是由外生重音和感受器官状态调控的。[translate]...
DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This aminoacid residue is highly conserved in ...
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 2004; 119: 861–872. Article CAS PubMed Google Scholar Song H, Hollstein M, Xu Y . p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 2007; 9: ...