The regulation of AMPK 1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathwaysJ. Cancer research, 2007, 67(7): 3043-3053. 29、5. Budanov A V, Karin M. p53 target genes sestrin1 and ...
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth TP53 (which encodes p53 protein) is the most frequently mutated gene among all human cancers. Prevalent p53 missense mutations abrogate its tumour suppressive function and lead to a ‘gain-of-function’ (GOF) that prom...
[12] LEVINE A J. p53: 800 million years of evolution and 40 years of discovery [J]. Nat Rev Cancer, 2020, 20(8): 471-80. [13] MARSHALL C B, MAYS D J, BEELER J S, et al. p73 Is Required for Multiciliogenesis and Regulates the Fox...
[9] Rekhi B, Karnik N, Agrawal R, Shetty O, Patkar S. Detection of MDM2 gene amplification on tissue microarray-based Fluorescence In-Situ Hybridization (FISH) in well-differentiated and dedifferentiated liposarcomas, displaying a ...
MD安德森癌症研究中心癌症预后不佳，化疗效果差都与P53突变相关 急性髓细胞白血病患者的基因突变及其预后意义 在2020年第62届ASH年会上，在关于急性髓细胞白血病患者的基因突变及其预后意义的主题中(Room ID: 613),来自德克萨斯大学MD安德森癌症中心的NJ.Short教授作为oral讲者为我们介绍了关于TP53基因突变VAF值高低对初发...
疾病背景介绍p53基因是一种肿瘤抑制基因(tumor suppressor gene),是最早发现的抑癌基因之一。该基因编码一种分子量为43.7KDa的蛋白质,但因蛋白条带出现在Marker所示53KD...
GENE THERAPY: Introgen Advances p53 for Cancer
19.Kastan, Michael B , and E. Berkovich . "p53: a two-faced cancer gene. " Nature Cell Biology 9.5(2007):489-91. 20.Eliyahu D, Goldfinger N, Pinhasi-Kimhi O, et al. Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene, 3.3 (1988):313-21 21.Johnson, ...
The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type p53 can suppress tumour development by multiple pathways. However, mutation of TP53 and the resultant inactivation of p53 allow evasion of tumour cell death and rapid tumour progression. The high frequency of...
The study of p53 has revealed many of the principles underlying human tumorigenesis. These include the critical differences between an oncogene and a tumor suppressor gene, the relationship between environmental exposures and cancer, the mechanisms through which cancer genes stimulate cell birth or inhibi...