such as PROTACs and molecular glues. PROTAC technology is a valuable platform for driving the degradation of target proteins. ARV-110 (alias bavdegalutamide) and ARV-471 (alias vepdegestrant) represent the forefront of PROTAC drug development in clinical trials...
Pax 3 stimulates p53 ubiquitination and degradation independent of transcription. PLoS ONE 2011; 6(12): e29379.Wang XD, Morgan SC, Loeken MR (2011) Pax3 stimulates p53 ubiquitination and degradation independent of transcription. PLoS One 6(12):e29379, :10.1371/journal.pone.0029379 Central...
CHIP is a chaperone associated ubiquitin ligase that has been shown to exhibit tumor suppressive effects through catalyzing the ubiquitination and subsequent degradation of several oncogenic proteins such ErbB2, c-myc, mutant p53, and NF-κB [126], [127], [128], [129]. CHIP has also been ...
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells. Mol Cancer Res 2008; 6: 873–83. Article CAS PubMed PubMed Central Google Scholar Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, et al. DNMT1...
Moreover, increased abundance of Tip60 results in increased acetylation of DNMT1, which in turn triggers the ubiquitination of DNMT1 by UHRF1. This sequence of events results in proteasomal degradation of DNMT1. In contrast, HAUSP and HDAC1 protect DNMT1 from degradation through deubiquitination ...
Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubi...
serves as a signal for protein degradation by the proteasome or for other outcomes such as endocytosis, degradation by the lysosome or directing these proteins to specific cellular compartments. This review discusses aspects of the regulation of EMT by ubiquitination and the UPS and underlines its co...
of the ubiquitinated proteins are targeted to the 26S proteasome for degradation. The ubiquitin/26S proteasome system constitutes the major protein degradation pathway in the cell. In recent years, the importance of the ubiquitination machinery in the control of numerous eukaryotic cellular functions ...
Kalejta and Shenk, 2003 R.F. Kalejta, T. Shenk Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein Proc. Nat. Acad. Sc.i U.S.A., 100 (2003), pp. 3263-3268 Google Scholar Khattar et al., 1995 S.K....
In addition, each component of LUBAC regulates breast cancer development through mechanisms independent of LUBAC activity. For example, HOIP associates with the p53/MDM2 complex and facilitates p53 polyubiquitination and degradation by stabilizing MDM2 in breast cancer cells [111]. Similarly, SHARPIN also...