Niclosamide promoted formation of polyubiquitinated Tax protein aggregate, facilitating its subsequent degradation in proteasome. Consistent with niclosamide-mediated Tax degradation, the transcription of HTLV-1 viral genes is suppressed. Furthermore, niclosamide inhibited the activities of MAPK /ERK and ...
The present study shows a novel antiviral mechanism of ISGs and elucidated that ISG12a recruits an E3 ligase, SKP2, for ubiquitination and degradation of viral protein and restricts viral infection. These findings provide important insights into exploring the working principles of innate immunity. ...
We found that the ubiquitin-dependent degradation of Rpn4 can be mediated by six different lysines. Interestingly, we showed through in vivo and in vitro assays that lysine 187 is selected for ubiquitination when all other lysines are available. To the best of our knowledge, this is the ...
In this study, we show that inhibition of p53 causes ubiquitination and down-regulation, through increased degradation, of the IGF-1R in human malignant melanoma cells. This effect, which was independent of the p53 status (i.e., wild type or mutated), was prevented if Mdm2 was coinhibited....
aIt is important to remark that in this study degradation of batteries was not considered. 陈述那在电池的这研究退化未被考虑是重要的。[translate] a神祗 God respectfully u 0662[translate] a我会爱你到永远,即使你不再爱我了 I can like you arriving forever, even if you no longer loved me[tran...
We also characterized the previously reported O6-BG-induced degradation of in HT-29 cell extracts [Pegg et al. (1991) 12, 1679-1683] and showed the extracts to be active in of the protein with . The proteolysis of O6-BG-inactivated in HT-29 cell extracts was energy-dependent and was ...
Here, we demonstrate that IRP2 is oxidized and ubiquitinated in cells before degradation. Moreover, iron-dependent oxidation converts IRP2 into a substrate for ubiquitination in vitro. A regulatory pathway is described in which excess iron is sensed by its ability to catalyze site-specific ...
We conclude that SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1. 展开 关键词: PROTEINS CELLCYCLE DOI: 10.1016/j.molcel.2006.09.007 被引量: 546 年份: 2006 ...
The ubiquitination site of Cdk5 appears to be in the p35 binding area; in the presence of high levels of p35, the ubiquitination of Cdk5 was blocked, and the degradation in S phase was attenuated. The data suggest an unsuspected role for Cdk5 during the progression of a normal cell cycle...
Activity-Dependent UbiquitinationDegradationTraffickingGlua2The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine ... J Widagdo,V Anggono - 《Oncotarget》 被引量: 7发表: 2015年 Subunit-Specific Augmentation of AMPA Receptor Ubiquitination by Phorbol Ester...