In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation. Xenopus egg extracts present many advantages for the study of the cell cycle, including the availability of a large quantity of material synchronized at a ...
New Ubiquitin-Mediated Protein Degradation Mechanism:新的泛素介导的蛋白降解机制泛素,蛋白,帮助,泛素降解,蛋白质,蛋白降解 文档格式: .pdf 文档大小: 82.28K 文档页数: 2页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 外语学习--英语学习 ...
Modes of regulation of ubiquitin-mediated protein degradation The ubiquitin-proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin-mediated degradation is involved ... D Kornitzer,A Ciechanover - 《Journal of Cellular Physiology》 被引量: 823发表: ...
Protein degradation is responsible for protein homeostasis and quality control of proteins, and one of the many cellular functions modulated by the ubiquitin-proteasome pathway.
A proteolytic pathway in which attachment of a small protein, ubiquitin, marks the substrates for degradation by a multi-subunit complex called the proteasome has been shown to function in synaptic plasticity and in several other physiological processes of the nervous system. Attachment of ubiquitin ...
Hepatitis B virus X protein enhances Myc stability by inhibiting SCF(Skp2) ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis. The stability of Myc oncoprotein is regulated by Skp/cullin/F-box (SCF) ubiquitin E3 ligase, in particular, via either SCF(Skp2) or SCF(Fb...
K. The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications. Eur. J. Cancer 40, 2217–2229 (2004). Article CAS PubMed Google Scholar Orlowski, R. Z. et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J...
Altogether, these data suggested that UbInPD is primarily (but not exclusively) mediated through C-degrons. Ubiquitination is not required for proteasomal degradation of UbInPD substrates bearing C-degrons To confirm that the candidate UbInPD substrates were not ubiquitinated in cells, we monitored ...
Recently, a Legionella pneumophila effector protein was shown to have an unprecedented ATP-independent ubiquitin ligase activity that couples phosphoribosylated ubiquitin (PR-Ub) to serine residues of host proteins. A new study published in Cell Research by Qiu et al. reveals that another Legionella ...
APP was tested as a substrate for degradation, using both the extracellular and the intracellular forms of APP770, APP751 and APP695. The intracellular APP forms did not show appreciable ubiquitin-mediated degradation. In contrast, the three extracellular forms of APP were degraded in vitro by ...