(2003). Ubiquitin-dependent degradation of the yeast Matα2 repressor enables a switch in developmental state. Genes Dev. 17, 2259-2270.Laney JD, Hochstrasser M (2003) Ubiquitin-dependent degradation of the yeast Matα2 repressor enables a switch in developmental state. Gene...
Here we investigate the fate of activated Smad2. We show that receptor-mediated activation leads to multi-ubiquitination and subsequent degradation of Smad2 by the proteasome. Ubiquitination of Smad2 is a consequence of its accumulation in the nucleus. If degradation is averted, the phosphorylated Smad...
Ubiquitin tags proteins for protein degradation. The ubiquitination requires three different enzymatic activities, a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2 or Ubc) and a ubiquitin ligase (E3). The action of all three enzymes leads to the establishment of a poly-ubiquit...
Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit. Rev. Biochem. Mol. Biol. 2015; 50 :1–17.Zattas D, Hochstrasser M. Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol 2015...
We conclude that Src kinase activity can be downregulated, not only by inactivation by Csk, but also by ubiquitin–proteasome-dependent degradation. Phosphorylation by Csk induces a conformational change in Src through intramolecular interactions that convert it from the open to the closed conformation....
modification of protein carbohydrate side chains and in Ubiquitin modifications and/or the Ubiquitin-dependent degradation of proteins, suggesting that these ... N Staudt,A Molitor,K Somogyi,... - 《Plos Genetics》 被引量: 65发表: 2005年 The role of E3 ligases in the ubiquitin-dependent regula...
Ubiquitin-dependent Degradation of Certain Protein Substrates in Vitro Requires the Molecular Chaperone Hsc70 Degradation of a protein via the ubiquitin system involves two discrete steps, signaling by covalent conjugation of multiple moieties of ubiquitin and degr......
Degradation of a protein via the ubiquitin system involves two discrete steps, signaling by covalent conjugation of multiple moieties of ubiquitin and degradation of the tagged substrate. Conjugation is catalyzed via a three-step mechanism that involves three distinct enzymes that act successively: E1,...
Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1 来自 国家科技图书文献中心 喜欢 0 阅读量: 51 作者: SHIGETSUGU HATAKEYAMA,MICHIKO SHIRANE 摘要: Activation of the transcription factor nuclear factor kappa B (NF-kb...
ubiquitin-and proteasome-dependent degradation问题补充:匿名 2013-05-23 12:21:38 泛素- 蛋白酶体依赖性降解 匿名 2013-05-23 12:23:18 ubiquitin和蛋白酶的退化 匿名 2013-05-23 12:24:58 ubiquitin和proteasome依赖退化 匿名 2013-05-23 12:26:38 泛素-和蛋白酶体依赖退化 匿名 2013-05-...