TMPO‐AS1miR‐126‐5pBRCC3PI3K/Akt/mTOR pathwayBackground Gastric cancer (GC) is an aggressive tumor featured by uncontrolled cell proliferation and metastasis. In recent years, long noncoding RNAs (lncRNAs) act as crucial regulators and biological markers in multiple cancers. LncRNA TMPO〢S1 has...
为此,作者试图研究FOXD1-AS1是否在GC中调控PI3K/AKT/mTOR信号通路。因此,作者发现FOXD1-AS1耗尽降低了MKN45和AGS细胞中PI3K、AKT和mTOR的磷酸化水平,而不是总水平(图4A),表明FOXD1-AS1在该通路中正调控。进一步,为了证实FOXD1...
OIP5-AS1 upregulated the peroxisome proliferator–activated receptor-γ (PPAR-γ) mRNA level to regulate adenosine monophosphate–activated protein kinase (AMPK)/v-akt murine thymoma viral oncogene homolog (Akt)/mammalian target of rapamycin (mTOR) signalling by interacting with FUS. PPAR-γ ...
IFN-γ调控MACC1-AS1/MACC1/AKT/mTOR轴抑制胰腺癌进展的分子机制探索 胰腺癌的发病率及死亡率在世界范围内不断上升.近年来多学科的发展及协作模式,胰腺癌诊断水平有所提高.随着腹腔镜技术,机器人等外科手术的发展,立体定向放射治疗等局部... 石小燕 - 广西医科大学 被引量: 0发表: 2022年 Effects of curcumin...
We further verified that BVES-AS1-201-50aa targeted and activated the Src/mTOR signaling pathway in CRC cells by co-immunoprecipitation (Co-IP) experiment, qualitative proteomic analysis, and western blotting. Our findings demonstrated that BVES-AS1 could encode a micro-...
mTOR-AKT信号通路目的研究ZSCAN16-AS1在肝癌发生发展中的生物学功能和潜在分子机制.方法通过临床数据库GEPIA和25例肝癌临床样本验证ZSCAN16-AS1在肝癌中的表达属性;利用siRNA介导敲低ZSCAN16-AS1表达,采用细胞增殖实验和克隆形成实验验证其在肝癌发生发展中的作用.探索ZSCAN16-AS1调控基因在25组肝癌临床样本中的表达...
细胞凋亡水平显著低于si-HOXD-AS1组.相比于si-NC组,si-HOXD-AS1组HeLa细胞中PI3K,AKT,mTOR磷酸化水平表达显著降低(P<0.01),si-HOXD-AS1+miR-133a-3p inhibitor组HeLa细胞中PI3K,AKT,mTOR磷酸化水平均显著高于si-HOXD-AS1组(P<0.01).结论 lncRNA HOXD-AS1可通过靶向调控miR-133a-3p而调控PI3K/AK...
MACC1-AS1Pancreatic cancer (PC)AKT/mTOR pathwayClinical and Translational Oncology - Metastasis-related in colon cancer 1 (MACC1) is highly expressed in a variety of solid tumours, but its role in pancreatic cancer (PC) remains unknown...doi...
Inhibition of HIF1A-AS1 promoted starvation-induced hepatocellular carcinoma cell apoptosis by reducing HIF-1α/mTOR-mediated autophagyHepatocellular carcinoma cellsApoptosisStarvationHIF1A-AS1AutophagyCorrelation between HIF1A-AS1 levels and clinical features of HCC patients...
Additionally, SP1 could facilitate the tumorigenesis of TNBC cells in vitro and in vivo by regulating the AFAP1-AS1 expression. Furthermore, silenced AFAP1-AS1 suppressed the expression of genes in the mTOR pathway, such as eukaryotic translation initiation factor 4B (EIF4B), mitogen-activated ...