RAC1MTORC1自噬溶酶体再生细胞死亡炎症自噬是一个进化上保守的过程,在营养物质缺乏时溶酶体选择性降解细胞质组分以维持细胞及机体稳态.自噬是一种古老的防御机制,与免疫系统密切联系,对固有免疫和适应性免疫具有多重作用.促炎细胞因子和抗炎细胞因子可分别激活和抑制自噬.TNFAIP8L2/TIPE2 (tumor necrosis factor,alpha...
Rac1 appears to bind directly to mTOR and to mediate mTORC1 and mTORC2 localization at specific membranes. Binding of Rac1 to mTOR does not depend on the GTP-bound state of Rac1, but on the integrity of its C-terminal domain. This function of Rac1 provides a means to regulate mTORC1...
Our study reveals a novel role of TNFAIP8L2 in autophagy by regulating the RAC1-MTORC1 axis that supports its potential as a target for therapeutic treatment.Abbreviations: ALR: autophagic lysosome reformation; BafA1: bafilomycin A1; BMDMs: bone marrow-derived macrophages; Co-IP: Co-...
Furthermore, the in vivo experiments also indicated that IBAN promotes autophagy by downregulating Rac1-mTOR. Taken together, our results firstly revealed that IBAN enhances autophagy via inhibiting Rac1-mTOR signaling pathway, and thus alleviates Ang II-induced injury in endothelial cells....
Cell growth: RAC1 sizes up mTORdoi:10.1038/nrm3124Schuldt, AlisonNature Publishing GroupNature Reviews Molecular Cell BiologySchuldt A: Cell growth: RAC1 sizes up mTOR. Nature reviews Molecular cell biology 2011, 12:343. :
Enhancement of autophagy by simvastatin through inhibition of Rac1- mTOR signaling pathway in coronary arterial myocytes. Cell. Physiol. Biochem. 31, 925-937.Enhancement of autophagy by simvastatin through inhibition of Rac1-m TOR signaling pathway in coronary arterial myocytes. Wei YM,Li X,Xu M...
Pharmacological inhibition of the mTOR pathways or exposure of neurons to cell permeable Rac1-mTOR complex blocking peptides prevented CCR. Finally, comparison of WT versus tau KO neurons established that tau is upstream of the mTOR complexes. Conclusions These results support a model in which beta...
YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathwayHepatocellular carcinoma, Yes-associated protein (YAP), Multi-drug resistance, Autophagy-related cell deathBackgroundMulti-drug resistance is the major cause of ...
KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells. Cell Biochem Funct, 2009, 27(1): 40-47.ChoiU J,JeeB K,Lim Y,Lee K H.KAI1/CD82decreases Rac1 expression and cell proliferation through PI3K/Akt/ mTORpathwayin H1299...
Here, we show that tuberous sclerosis complex 1 (TSC1) functions centrally in OCLs to promote podosome organization and bone resorption through mechanistic target of rapamycin complex 1 (mTORC1) and the small GTPases Rac1/Cdc42. During osteoclastogenesis, enhanced expression of TSC1 downregulates ...