MTORC1自噬溶酶体再生细胞死亡炎症自噬是一个进化上保守的过程,在营养物质缺乏时溶酶体选择性降解细胞质组分以维持细胞及机体稳态.自噬是一种古老的防御机制,与免疫系统密切联系,对固有免疫和适应性免疫具有多重作用.促炎细胞因子和抗炎细胞因子可分别激活和抑制自噬.TNFAIP8L2/TIPE2 (tumor necrosis factor,alpha-...
[6].2020 年发表的研究表明,RAC1 可以促进食管 癌细胞的生存能力,在食管癌细胞中下调 RAC1 可以通过阻断 phosphoinositide 3-kinase/AKT/mTOR 通路来抑制食管癌细胞的 增殖,侵袭和迁移[9].最新研究报道,转移性前列腺癌相关基 因编码蛋白 DEPDC1B 能通过与 RAC1 结合,激活 PAK1 通路, 诱导上皮间充质转化(...
另一方面,机械应力下调了哺乳动物雷帕霉素靶标(mTOR)通路的多个靶点,包括p70-S6K_pT389、Rictor_pT1135、4E-BP1_pS65和mTOR_pS2448,它们促进蛋白质合成和细胞生长增殖(图1 A)。为了评估机械应力如何改变信号通路,计算了九个主要...
Rac1 appears to bind directly to mTOR and to mediate mTORC1 and mTORC2 localization at specific membranes. Binding of Rac1 to mTOR does not depend on the GTP-bound state of Rac1, but on the integrity of its C-terminal domain. This function of Rac1 provides a means to regulate mTORC1...
另一方面,机械应力下调了哺乳动物雷帕霉素靶标(mTOR)通路的多个靶点,包括p70-S6K_pT389、Rictor_pT1135、4E-BP1_pS65和mTOR_pS2448,它们促进蛋白质合成和细胞生长增殖(图1 A)。为了评估机械应力如何改变信号通路,计算了九个主要通路的通路评分,发现细胞周期通路的多个蛋白质成员(p27_pT157,细胞周期蛋白E1、B1、...
Molecular studies in rodent models have identified several signaling pathways that are altered in CDD, including protein kinase B (AKT) and mechanistic target of rapamycin (mTOR), AKT and glycogen synthase kinase-3 beta (GSK-3b), and brain derived neurotropic factor and Ras-related C3 botulinum...
The mammalian target of rapamycin (mTOR) pathway, which regulates the cell size, was more strongly suppressed in the podocytes of Rac1 cKO mice than in those of control mice under pathological conditions. In accordance with this result, the volumes of podocytes in Rac1 cKO mice were ...
Cell growth: RAC1 sizes up mTOR Cell growth: RAC1 sizes up mTORNature Reviews Molecular Cell Biology 12, 343 (2011). doi:10.1038/nrm3124Author: Alison SchuldtRAC1 regulates m... Schuldt,Alison - 《Nature Reviews Molecular Cell Biology》 被引量: 3发表: 2011年 MTORC1 and mTORC2 Regulate ...
Aw, Wen Yih et al.Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formationScience Advances2023 ISSN 2375-2548 Dong, Yuqing et al.CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis...
Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells 2019, Proceedings of the National Academy of Sciences of the United States of America PI3Kβ - A versatile transducer for GPCR, RTK, and small GTPase signaling 2019, Endocrinology The origins and...